酚噻嗪类药物对血清载脂蛋白、脂蛋白含量的影响  

The effects of phenothiazines drugs on serum apoliprotein and lipoprotein level

作　　者：文芳[1] 程自立[1] 白雪光[1] 臧德馨[1] 林琼[1] 万均成[1] 

机构地区：[1]湖北医科大学神经精神病研究所

出　　处：《中华精神科杂志》1998年第2期108-110,共3页Chinese Journal of Psychiatry

摘　　要：目的探讨长期（平均６年）接受酚噻嗪类药物治疗的慢性精神分裂症患者血清载脂蛋白含量变化及其危险因素。方法采用酶法及火箭免疫电泳法对１５１例精神分裂症患者和１００名健康人血清胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬＣ）、载脂蛋白ＡⅠ（ａｐｏＡⅠ）、载脂蛋白Ｂ（ａｐｏＢ）的水平进行了对比分析。结果精神分裂症患者ａｐｏＡＩ，ａｐｏＡＩ／ａｐｏＢ，ＨＤＬＣ含量均低于正常对照组（Ｐ＜０．０１），ＴＧ、ａｐｏＢ水平却高于正常对照组（Ｐ＜０．０１），而ＴＣ浓度与正常对照组之间差异无显著性（Ｐ＞０．０５）。结论长期服用酚噻嗪类药物的精神分裂症患者存在载脂蛋白代谢紊乱，在治疗精神分裂症的同时应及早采取相应的预防措施。Objective The purpose of this study was to investigate the serum apoliprotein level in chronic schizophrenia with long term phenothiazines treatment (average 6 years). Methods Serum apolipoprotein AI (apoAI), apolipoprotein B (apoB), high density lipoprotein cholesterol (HDL C), total cholesterol (TC), and triglyceride (TG) levels were measured in 151 chronic schizophrenia patients and 100 normal controls using the rocket immunoelecrophoresis method. Results ApoAI/apoB, HDL C levels were significantly lower in schizophrenic patients than that in normal controls, but TG and apoB levels were significantly higher in patients than that in controls. No difference was noted in TC concentration between patients and patients. Conclusion It is suggested that a disturbance of apoliprotein metabolism exists in schizophrenic patients with long term phenothiazines treatment. It is necessary to take preventive measures and test the parameters related with apoliprotein periodically while schizophrenic patients are treated with phenothiazines.

关 键 词：精神分裂症 酚噻嗪类 载脂蛋白类 脂蛋白类 

分 类 号：R971.4[医药卫生—药品]