O^7-位硝酸酯类白杨素衍生物的合成及其促血管生成作用  

Synthesis and Evaluation of Promoting Angiogenesis of O^7-(Nitro-oxyalkyl)chrysins

作　　者：丁华兰[1] 彭圣明[1] 刘展鹏[1] 林原斌[1] 邹晓青[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105

出　　处：《中国医药工业杂志》2009年第3期174-177,共4页Chinese Journal of Pharmaceuticals

基　　金：湖南省教育厅项目(05C079)

摘　　要：白杨素在碳酸钾作用下,与二溴亚烷烃发生亲核取代,再和硝酸银反应,使7-羟基与NO供体片段相连,得到3个新的O7-位硝酸酯类白杨素衍生物3a～3c,结构经1HNMR、MS确证,并采用鸡胚绒毛尿囊膜(CAM)技术初步考察了目标化合物的促血管生成作用。O^7- （Nitro-oxyalkyl） chrysins were prepared by the condensation of chrysin and alkylene dibromide followed by the reaction with AgNO3, and their structures were confirmed by 1HNMR and MS. The three target compounds were evaluated for their positive effect on promoting angiogenesis with chicken chorioallantoic membrance technology.

关 键 词：硝酸酯 NO供体 白杨素 合成 促血管生成 

分 类 号：R972[医药卫生—药品]