3-羟甲基头孢菌素中间体的制备  

Preparation of 3-hydroxymethyl cephem intermediate

作　　者：周晓靓[1] 王浩[1] 吕茜茜[1] 施培基[1] 

机构地区：[1]中国医学科学院放射医学研究所,天津300192

出　　处：《中国抗生素杂志》2009年第3期156-157,192,共3页Chinese Journal of Antibiotics

基　　金：天津市自然基金资助(项目编号06YFJMJC10300)

摘　　要：头孢菌素类的结构改造常需要含不同侧支链的头孢菌素母核,本文以7-ACA为原料,一锅法制备7位与4位均有保护基的3-羟甲基头孢菌素中间体。该工艺具有反应条件温和、操作简便且产品纯度好、收率高的优点,适于工业化生产。7-amino 3-hydroxymethyl cephem（7-AHCA） is a very useful cephalosporin nuclei. It was prepared from 7-ACA via one pot synthesis to gain the protected intermediate. The intermediate is validated for rebuilding of various cephalosporin nuclei. This method is characterized by moderate reaction conditions, simple operation, high purity and high yield rate products, so the process has the potential application to the industry production.

关 键 词：7-氨基-3-羟甲基头孢烷酸(7-AHCA) 四丁基氢氧化铵 7-ACA 制备 

分 类 号：R978.11[医药卫生—药品]