阴沟肠杆菌耐药机制的研究进展  

Research Progress on Drug Resistance Mechanisms of Enterobacter cloacae

作　　者：刘军[1] 李国明[1] 

机构地区：[1]广东医学院微生物学教研室,湛江524023

出　　处：《国外医药（抗生素分册）》2009年第2期49-53,75,共6页World Notes on Antibiotics

摘　　要：阴沟肠杆菌耐药机制主要包括产生β-内酰胺酶、qnr基因介导耐药、整合子、主动外排泵系统作用、药物作用靶位的改变、外膜通透性改变等。阴沟肠杆菌耐药机制的研究对于控制耐药菌的播散和合理使用抗生素都具有重要的意义。The drug resistance mechanisms of Enterobacter cloacae mainly include producing β -lactamases, qnr gene mediated resistance, existence of integron or active etttux pump system, alterations of drug target and outer membrane permeability, and so on. Understanding the drug resistance mechanisms of E. cloacae plays a crucial role in preventing spread of their resistance and enhancing a more rational Use of antibiotics. In this review, the current research progress on the above-mentioned drug resistance mechanisms of E. cloacae were described.

关 键 词：阴沟肠杆菌 耐药机制 Β-内酰胺酶 整合子 

分 类 号：Q939.92[生物学—微生物学]