局部肾素-血管紧张素-醛固酮系统与糖尿病肾病的治疗  

Local renin-angiotensin-aldosterone system and the treatment of diabetic nephropathy

作　　者：徐茜[1,2,3] 汤正义[1,2,3] 杨洋[1,2,3] 田秀丽[1,2,3] 黄佳佳[1,2,3] 王卫庆[1,2,3] 宁光[1,2,3] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌科 [2]上海市内分泌代谢病临床中心 [3]上海市内分泌代谢病研究所

出　　处：《世界临床药物》2008年第11期647-650,共4页World Clinical Drug

摘　　要：循环中肾素-血管紧张素-醛固酮系统(RAAS)成分由分布于全身的组织细胞合成与分泌。糖尿病时,肾脏局部肾素、血管紧张素(Ang)Ⅱ、醛固酮等活性增加,它们作用于血管或通过激活炎症因子等途径,导致肾血管病变及肾纤维化。动物试验与临床研究表明,抑制RAAS可延缓糖尿病肾病进程。Ingredients of renin-angiotensin-aldosterone system （RAAS） are synthesized and secreted from local tissues and cells distributed among all the body in blood circulation. Under diabetic situation, the activities of renin, angiotensin II and aldosterone are increased within kidney. These factors can induce renal vasculopathy and fibrosis by the activation of blood vessels and inflammatory factors. Researches on animal models and human clinical trials have suggested that the progression of diabetic nephropathy could be delayed by the inhibition of RAAS.

关 键 词：糖尿病肾病 局部 肾素-血管紧张素-醛固酮系统 血管紧张素Ⅱ 醛固酮 炎症因子 

分 类 号：R544.1[医药卫生—心血管疾病] R587.2[医药卫生—内科学]