氯沙坦对老年高血压患者左室肥厚及血浆转化生长因子β1的影响  

Effects of losartan on left ventricular hypertrophy and plasma transforming growth factor-β1 in elderly patients with hypertension

作　　者：邬真力[1] 许顶立[1] 李杨[1] 赖文岩[1] 黄鹏[1] 白书昌 苏亮[1] 

机构地区：[1]南方医科大学南方医院心内科,广东广州510515

出　　处：《南方医科大学学报》2009年第3期531-533,共3页Journal of Southern Medical University

摘　　要：目的观察氯沙坦对老年高血压患者左室肥厚的影响及血浆转化生长因子β1(TGF-β1)变化的意义。方法将老年原发性高血压患者分为伴左室肥厚组(EH+LVH组)和不伴左室肥厚组(EH组),给予氯沙坦治疗6个月,比较治疗前、后患者血压、超声心动图指标、血浆TGF-β1的变化。结果经过氯沙坦治疗后,EH+LVH组和EH组血压较治疗前显著降低(P<0.01)。EH+LVH组室间隔厚度、左室后壁厚度较治疗前显著减低,E/A显著升高,左室重量指数(LVMI)显著降低(P<0.01),同时EH+LVH组血浆TGF-β1较治疗前显著降低(P<0.01);而EH组血浆TGF-β1较治疗前无显著性变化(P>0.05)。相关性分析显示,血浆TGF-β1水平与LVMI呈正相关(P<0.01),而与收缩压、舒张压无显著相关性(P>0.05)。结论伴左室肥厚的老年高血压患者血浆TGF-β1升高,降低TGF-β1表达,可能是氯沙坦逆转老年高血压患者左室肥厚的机制之一。Objective To investigate the effects of losartan on left ventricular hypertrophy （LVH） and plasma transforming growth factor-β1 （TGF-β1） in elderly patients with essential hypertension （EH）. Methods The elderly patients with EH were divided into two groups, namely EH＋LVH group and EH group according to the data of echocardiogram. The systolic and diastolic blood pressures of the patients were monitored. Plasma TGF-β1 was measured before and after 6 months＇ treatment with losartan, and the relationship between TGF-β1 and other index were analyzed. Results After 6 months＇ treatment, the blood pressure of EH＋LVH group and EH group were significantly lowered （P〈0.01）. Significant improvement of IVSTd, LVPWd, E/A, and LVMI （P〈0.01） and obvious reduction of plasma TGF-β1 （P〈0.01） occurred in EH＋LVH group after 6 months＇ treatment. Correlation analyses indicated that the plasma TGF-β1 level was positively correlated to LVMI （P〈0.01）. Conclusion Losartan can reversed LVH in elderly patients with EH partially by lowering plasma TGF-β1 level.

关 键 词：氯沙坦 高血压 左室肥厚 转化生长因子 

分 类 号：R541.3[医药卫生—心血管疾病]