气道中心性肺间质纤维化(附1例报告)  

AIRWAY-CENTERED PULMONARY INTERSTITIAL FIBROSIS:A CASE REPORT

作　　者：魏志敏[1] 姜天福[1] 赵鹏[1] 纪祥瑞[1] 李霞[1] 孙玲玲[1] 

机构地区：[1]青岛大学医学院附属医院病理科,山东青岛266003

出　　处：《青岛大学医学院学报》2009年第2期165-166,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的提高对气道中心性肺间质纤维化(ACIF)的认识。方法对1例确诊为ACIF病人的临床资料进行分析。结果ACIF是弥漫性肺纤维化一种特殊形式,影像学表现为双肺弥漫性分布斑片状、结节状密度增高影,小叶结构增粗。病理学特征:以细支气管为中心,管壁周围纤维组织增生伴平滑肌增生。病因及发病机制不清楚,可能与职业接触史有关。临床表现为慢性咳嗽、胸闷憋气、活动后呼吸困难。诊断需结合临床、影像学、病理学改变。结论ACIF具有独特的影像学和组织病理学特点,需要与间质性肺炎鉴别。Objective To better understand the characteristics of airway-centered pulmonary interstitial fibrosis （ACIF）. Methods With a review of the literature, this case of ACIF was analyzed. Results ACIF was an unusual form of diffused lung fibrosis. Imageologically, a dense patching or nodosity could be seen, wih a thickened folial structure. The pathological features ineluded fibrosis and hyperplasia of smooth muscles around the bronchioles. The clinical manifestations were chronic cough, chest distress, and dyspnea after activity. The diagnosis depended on clinical manifestations, imageology and pathology. The etiology of ACPIF was still unknown, but the patients probably had a history of exposure to some harmful factors. Conclusion ACIF possesses specific imageological and histopathological features, which should be differentiated from interstitial pneumonia.

关 键 词：肺疾病 间质性 气道中心性肺间质纤维化 诊断 

分 类 号：R563.9[医药卫生—呼吸系统]