乙肝疫苗无、弱应答危险因素的病例对照研究  

THE CASE-CONTROL STUDY OF RISK FACTORS OF NON OR HYPO-RESPONSE TO HEP-ATITIS B VACCINE

作　　者：黄晓晖[1] 陈思东[1] 

机构地区：[1]广东药学院公共卫生学院,广州510310

出　　处：《现代预防医学》2009年第6期1003-1005,共3页Modern Preventive Medicine

基　　金：广东省自然科学基金(020537)

摘　　要：[目的]探讨乙肝疫苗无、弱应答的危险因素。[方法]选取1342名接种乙肝疫苗后无、弱应答者128人作为病例组,在有应答者中按性别匹配随机抽取128人作为对照组进行病例对照研究,对所有研究对象进行问卷调查,采用SPSS13.0软件对获取的研究数据进行单因素分析以及多因素Logistic回归分析。[结果]单因素分析发现,与无、弱应答相关的环境因素为年龄(OR=2.52,95%CI1.51～4.21)、BMI(OR=2.38,95%CI1.13～5.02)、吸烟(OR=2.15,95%CI1.08～4.28)、饮茶(OR=0.32,95%CI0.10～0.99);多因素Logistic回归分析,最终进入模型的有年龄(OR=2.331,95%CI1.357～4.004)、BMI(OR=2.439,95%CI1.148～5.184)和饮茶(OR=0.643,95%CI0.414～0.998)。[结论]无、弱应答的发生与多种因素有关。[Objective] To study the risk factors of non-or hypo-response to hepatitis B vaccine. [Methods] A casecontrol study which Out of 1342 patients vaccinated with hepatitis B vaccine, 128 patients who showed non-or hypo-response to hepatitis B were recruited. And 128 patients with response to hepatitis B vaccine had randomly selected and matched with the cases by gender. All participants were investigated with a uniform questionnaire. Single factor analysis and multiple factor logistic analysis were performed by SPSS 13.0 software. [ Results] Univariate analysis indicated the factors had association with non-or hypo-response, such as age （ 0R=2.52, 95%CI 1.51-4.21） , BMI （OR=2.38, 95%CI 1.13-5.02） , smoking （OR= 2.15, 95%CI 1.08-4.28） and tea （OR=0.32, 95%C1 0.10-0.99）. The results of multivariate logistic regression showed that only three factors were entered in the model including age （OR=2.331. 95%CI 1.357-4.004）, BMI （OR=2.439, 95%CI 1.148- 5.184） and tea （OR=0.643, 95%CI 0.414-0.998）. [Conclusion] Many factors were associated with non-or hyporesponse.

关 键 词：乙肝疫苗 无、弱应答 病例对照研究 

分 类 号：R186[医药卫生—流行病学]