CEA、CYFRA21-1、CA153联合检测鉴别结核性积液与癌性积液的对比分析  

COMPARATIVE ANALYSIS OF COMBINATION OF CEA,CYFRA21-1 AND CA153 IN DE-TECTION AND DIFFERENTIAL DIAGNOSIS OF TUBERCULAR PLEURAL EFFUSION AND MALIGNANT PLEURAL EFFUSION

作　　者：美朗曲措[1] 张永刚[1,2] 范红[1,2] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041 [2]四川大学华西医院文验医学科

出　　处：《现代预防医学》2009年第6期1140-1141,1146,共3页Modern Preventive Medicine

摘　　要：[目的]研究和评价CEA、CYFRA21-1、CA153在结核性及癌性积液中的临床应用及检验效能。[方法]选结核性积液患者144例,癌性积液患者131例,采用化学发光免疫法检测胸水及血清中的CEA、CYFRA21-1、CA153水平。[结果]癌性积液患者积液及血清的CEA、CYFRA21-1、CA153含量较结核性积液及血清内水平均明显增高,差异有统计学意义(P﹤0.01)。癌性积液中的CEA、CYFRA21-1、CA153含量明显高于血清中的CEA、CYFRA21-1、CA153含量。[结论]胸水CEA,CYFRA21-1、CA1533项指标联合检测,对恶性胸腔积液的敏感度为96.2%,特异度为91.7%,准确度为93.8%。联合检测CEA,CYFRA21-1、CA153含量对鉴别结核性与癌性胸腔积液有较高的临床价值。[ Objective ] To investigate and evaluate the diagnostic value and clinic application of combination of CEA. CYFRA21-1 and CA153 tubercular pleural effusion and malignant pleural effusion. [Methods] 144 cases with tubercular perfusion and 131 cases with malignant perfusion were collected, and CEA, CYFRA21-1 and CA153 in the pleural effusion and serum were detected by chemical luminal immunology. [ ReSults] The levels of CEA, CYFRA21-1 and CA153 in serum and malignant pleural effusion were significantly increased when compared with that in tuberecular pleural effusion or serum （P 〈 0.01 ）. The levels of CEA, CYFRA21-1 and CA153 in malignant pleural effusion were significantly higher than those in serum. [Conclusion] The sensitivity, specificity and accuracy of combination of CEA. CYFRA21-1 and CA153 in detection of malignant pleural effusion were 96.2vA, 91.7% and 93.8%, respectively. Combination of CEA. CYFRA21-1 and CA153 has high clinic application in detection and differential diagnosis of tubercular pleural effusion and malignant pleural effusion.

关 键 词：CEA CYFRA21—1 CA153肿瘤标志物 

分 类 号：R446.1[医药卫生—诊断学] R730.43[医药卫生—临床医学]