基于Monte Carlo荧光分子断层成像前向问题的研究  

Forward Problem of Fluorescent Molecular Tomography Based on Monte Carlo

作　　者：孙丹萍[1] 张涛[1] 张永红[1] 白净[1] 

机构地区：[1]清华大学生物医学工程系,北京100084

出　　处：《北京生物医学工程》2009年第1期1-5,共5页Beijing Biomedical Engineering

基　　金：国家自然科学基金（30670577,60571013）、清华-裕元基金、国家973计划（2006CB705700）、国家863计划（2006AA020803）、博士点基金

摘　　要：随着生物和光学技术的成熟，近红外荧光成像得到了飞速发展。荧光分子断层成像是以特定波长的光去激发荧光染料，使其吸收入射光，并发出波长长于入射光的近红外荧光。前向问题是进行光学成像研究的关键环节，可以指导实验以及重建算法。本文提出了一种基于Monte Carlo方法的荧光分子断层成像的光子传输模型，重点研究了激发光激发荧光的过程以及光子在生物体内的传播过程，在已知激发光源、传播介质、荧光物质等参数的条件下，得到荧光光子在CCD探测器上的分布情况，并且分别用理论和实验两种方法对算法的仿真结果进行了验证。With the development of biology and optical technique, fluorescent molecular tomography has become a hot research field. Fluorescent Molecular Tomography is carried out by using defined light to excite fluorochrome. When the fluorochrome absorbs enough energy, it emits light with a longer wavelength. Forward problem is the key step of optical imaging study that can guide the reconstruction and real experiments. In this paper, a photon propagation model of FMT based on Monte Carlo method was proposed, mainly focusing on the fluorescent excitation and photon propagation. With known quantities （ e. g. parameters of laser source, media, fluorescence）, the distribution of fluorescent photons was abtained. The result of the model was validated by analytical and experimental methods.

关 键 词：MONTE CARLO方法 荧光分子断层成像 激发荧光 光子传输 

分 类 号：R318.04[医药卫生—生物医学工程]