多培沙明对离体兔灌流心脏冠脉流量和左心室功能的影响  

EFFECT OF DOPEXAMINE ON CORONARY FLOW AND LEFT VENTRICULAR FUNCTION OF ISOLATED RABBIT HEART AND IN COMPARISON WITH FENOLDOPAM AND PROCATEROL

作　　者：秦富忠[1] 陈建民 赵荣瑞 樊变爱[2] 边茂 

机构地区：[1]山西医科大学第一医院 [2]山西省人民医院 [3]平鲁县人民医院

出　　处：《山西医药杂志》1998年第1期24-25,共2页Shanxi Medical Journal

基　　金：山西省自然科学基金

摘　　要：用离体兔正常心脏模型观察多培沙明（ＤＰＸ）对冠脉流量和左心室功能的影响，并与非诺多泮（ＦＯＤＡ）和丙卡特罗（ＰＣＴ）的效应做对比。结果表明，ＤＰＸ使正常心脏冠脉流量（ＣＦ），左室肌收缩功能（＋ｄｐ／ｄｔｍａｘ等）和心率（ＨＲ）均呈剂量依赖性增加，ＦＯＤＡ增加ＣＦ程度小于ＤＰＸ。ＰＣＴ对各指标作用最小，提示ＤＰＸ根据其增加ＣＦ和轻度正性肌力作用特性，对治疗缺血性左心功能不全有较好的前景。The influence of dopexamine (DPX) on coronary flow and left ventricular function was observed using normal isolated rabbit hearts,and comparing the effects of DPX with those of fenoldopam (FODA) and procaterol (PCT).DPX was found to produce dosedependent increases in coronary flow (CF),left ventricular contractile function (+dp/dt max,etc) and heart rate (HR);FODA increased the CF to a lesser degree than DPX did,whereas the effect of PCT was the least.These results indicated that DPX has a better prospect in the treatment of ischemic left ventricular dysfunction in view of its dual action of increasing CF and inotropism.

关 键 词：多培沙明 冠脉循环 左心室功能 缺血 药物疗法 

分 类 号：R541.05[医药卫生—心血管疾病]