选择性氢化还原制备4-氯-3,5-二氨基苯甲腈  

Preparation of 4-chloro-3,5-diaminobenzonitrile by selective hydrogenation reduction

作　　者：高乾善[1] 高光杰 胡建强 颜国刚[1] 

机构地区：[1]山东省分析测试中心,山东济南250014 [2]山东博士伦福瑞达制药有限公司,山东济南250101

出　　处：《化工中间体》2009年第3期30-33,共4页

摘　　要：利用瑞乃镍作催化剂，丙酮作溶剂，在加氢控制剂作用下将4-氯-3，5-二硝基苯甲腈（CDNBN）选择性氢化还原，得到4-氯-3，5-二氨基苯甲腈（CDABN）。文中探讨了温度、氢气压力、控制剂、催化剂等对反应的影响。确定了最佳生产工艺条件：反应温度40℃，氢气压力2.0-3.0MPa，CDNBN：控制剂：催化剂为40：1.0：4.0。实验结果证明，CDNBN平均转化率为98.7％，CDABN平均产率93.4％，重结晶后的平均产率为90.5％。using Raney Nickel as catalyst, acetone as solvent, by the action of hydrogenation control agent, the 4-chloro-3,5-diaminobenzonitrile （CDABN） was prepared by selective hydrogenation reduction from 4-chloro-3,5-dinitrobenzonitrile （CDNBN）. The effects on the reaction such as temperature pressure and control agent and catalyst were discussed. The optimum reaction conditions were confirmed as follows： the reaction temperature was 40℃, the pressure of hydrogen was 2.0-3.0MPa, the weight ratio of CDNBN：control agent：catalyst was 40：1.0：4.0. The results proved that the average ratio conversion of CDNBN is 98.7%and the average yield of CDABN is 93.4%（by HPLC）, the average yield by recrystallization is 90.5%.

关 键 词：4-氯-3 5-二硝基苯甲腈 4-氯-3 5-二氨基苯甲腈 选择还原 催化加氢 制备 

分 类 号：TQ241.15[化学工程—有机化工]