桑白皮中一个新的二氢黄酮苷类成分(英文)  

A New Flavanone Glycoside with Anti-proliferation Activity from the Root Bark of Morus alba

作　　者：张敉[1] 王荣荣[2] 陈曼[1] 张涵庆[1] 孙视[1] 张陆勇[2] 

机构地区：[1]江苏省中国科学院植物研究所,南京210014 [2]中国药科大学新药筛选中心,南京210009

出　　处：《中国天然药物》2009年第2期105-107,共3页

摘　　要：目的:研究桑白皮(Morus alba L.)的活性成分。方法:运用柱层析方法分离纯化,根据理化性质和波谱数据鉴定化合物,采用HO-8910细胞对化合物进行抗增殖活性测试。结果:从桑白皮中分离得到1个新的化合物,鉴定为5,2'-二羟基-7,4'-O-β-D-二吡喃葡萄糖二氢黄酮苷,它对HO-8910细胞48h,72h的IC50分别为3.68和1.87μmol·L·1。结论:从该中药材中分离得1个新的化合物,并发现它具有一定的抗人卵巢癌细胞HO-8910增殖的活性。AIM： To study the bioactive constituents from the root bark of Morus alba. METHODS： Compound 1 was separated and purified by silica gel chromatography and Sephadex LH-20 （MeOH）. Its structural identification was based on physical properties and spectroscopic analysis （including 2D NMR）. And it was tested for its anti-proliferation activity against HO-8910 cells. RESULTS： A novel flavanone glycoside, 5,2＇-dihydroxyflavanone-7,4＇-di-O-β-D-glucoside （steppogenin-7,4＇-di-O-β-D-glucosiade）, was isolated from the root bark of Morus alba. Its IC50 of 48 h and 72 h are 3.68, 1.87 μmol.L^-1, respectively. CONCLUSION： Compound 1 is a new flavanone glycoside and it shows significant inhibiting activity against human ovarian cancer HO-8910 cells＇ proliferation.

关 键 词：桑白皮 5 2’-二羟基-7 4’-O-β-D-二吡喃葡萄糖二氢黄酮苷 抗增殖 

分 类 号：R284.1[医药卫生—中药学]