含多个(2-羟甲基)咪唑基衍生物的合成新方法  

Novel Synthetic Method of Tri(2-hydroxymethyl) Imidazole Derivatives

作　　者：谭明[1] 蒋宗林[1] 王心良[1] 霍娜[1] 解雪乔[1] 苏晓渝[2] 谢如刚[2] 

机构地区：[1]西华师范大学化学化工学院,四川南充637009 [2]四川大学化学学院,四川成都610064

出　　处：《西华师范大学学报（自然科学版）》2009年第1期67-70,共4页Journal of China West Normal University(Natural Sciences)

基　　金：四川省教育厅自然科学基金重点项目(2004A103);西华师范大学科研项目启动基金资助项目(05B031)

摘　　要：咪唑与丙烯腈的Michael加成产物与37%甲醛在密闭状态下实现选择性2-羟甲基反应,所得产物与三苄溴季铵化,生成的季铵盐再经Hoffmann型消除反应,高产率地合成了2种含3个2-羟甲基咪唑基衍生物4a,4b,收率>91%.目标化合物的结构经IR,1HNMR,MS谱证实.本文报道的合成方法,操作简便,后处理容易,很好地解决了分离、纯化等问题.The target compounds 4a, 4b have been efficiently synthesized by tri（bromomethyl）benzene and 1-Cya- noethyl-2-hydroxymethylimidazole obtaining imidazolium salts, following by Hoffmann-type elimination. The 1-Cyanoethyl-2-hydroxymethylimidazole has been selectively gained by 1-cyanoethyl- imidazole which can be gotten by the Michael addition reaction of imidazole and acrylonitrile and 37% formaldehyde in a seal tube at 110℃. The yields of the target compounds are over 91%. And the target compounds have been confirmed by IR, ^1 HNMR and MS. The method reported by this article is easily operated and disposed, what＇ s more, it resolves the problem of separation and purification.

关 键 词：2-羟甲基咪唑 MICHAEL加成 季铵化 Hoffmann消除 合成 

分 类 号：O626.23[理学—有机化学]