猪带绦虫六钩蚴TSO45W基因工程疫苗研究进展  

TSO45W genetically engineering vaccine against Taenia solium oncosphere

作　　者：周必英[1,2] 陈雅棠[1] 李文桂[1] 

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所,重庆400016 [2]贵州省遵义医学院寄生虫学教研室,贵州遵义563003

出　　处：《中国病原生物学杂志》2009年第2期141-144,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.30801052,No.30671835,No.30500423和No.30200239)

摘　　要：囊虫病是一种危害严重的人兽共患寄生虫病。研制有保护性作用的疫苗将是控制和消灭该病的有效方法,猪带绦虫保护性抗原的研究是猪囊虫病免疫的基础。45W蛋白是猪带绦虫六钩蚴时期的重要抗原,但天然45W抗原来源有限,限制了其应用,而基因工程重组抗原的应用可解决质量控制和抗原来源的问题。本文就近年来国内外对猪带绦虫六钩蚴TSO45W基因工程疫苗的研究进展作一综述。Cysticercosis is a severe zoonotic disease caused by the larval stage （cysticercus cellulosae） of the helminth Taenia solium. Development of a highly effective practical vaccine is an effective measure for the control and eradication of cysticercosis. Study of protective antigens of T. solium is the basis for immunity of cysticercosis. 45W is an important antigen gene of T. solium oncosphere. Limited source of native antigen restricts its use. The application of recombinant antigen will solve the problem of antigen source and quality control. Recent research progress in TSO45 genetically engineering vaccine against T. solium oncosphere was reviewed in this article.

关 键 词：猪带绦虫 囊虫病 六钩蚴 重组45W抗原 疫苗 综述 

分 类 号：R383.32[医药卫生—医学寄生虫学]