α-硫辛酸与甲钴胺联合治疗糖尿病周围神经病变  

Single or combined therapy of α - lipoic acid and mecobalamin for diabetic peripheral neuropathy

作　　者：姜宏卫[1] 滕中杰[1] 马瑜瑾[1] 李利平[1] 付留俊[1] 刘婕[1] 宋白利[1] 

机构地区：[1]河南科技大学第一附属医院内分泌科,河南省洛阳市471003

出　　处：《中国医药》2009年第3期183-184,共2页China Medicine

摘　　要：目的观察α-硫辛酸与甲钴胺联合治疗糖尿病周围神经病变的疗效。方法将109例患者按随机数字表法分为α-硫辛酸组36例、甲钴胺组34例和联合治疗组39例，均以控制饮食、口服降糖药物和／或使用胰岛素严格控制血糖为基础治疗。α-硫辛酸组给予α-硫辛酸600mg／d静脉滴注；甲钴胺组给予甲钴胺500wg／d静脉滴注；联合治疗组联合应用α-硫辛酸600mg／d与甲钴胺500μg／d静脉滴注，3组均治疗3周。观察并比较3组的疗效。结果经过治疗，3组麻木症状皆有明显改善，联合治疗组总有效35例（92．1％），高于甲钴胺组24例（70．6％）及α-硫辛酸组25例（73．5％），差异有统计学意义（P〈0．05）。治疗后，3组痛觉视觉模拟评分也皆有明显降低。结论α-硫辛酸与甲钴胺联合治疗糖尿病周围神经病变疗效优于二者单独用药。Objective To observe the effect of the single or combined therapy of α-lipoic acid （ALA） and mecobalamin on diabetic peripheral neuropathy （DPN）. Methods A total of 109 DPN cases were randomized into 3 groups. They were given the drug of ALA （ALA group, n =36）, or meeobalamin （mecobalamin group, n =34） , or combination therapy （ combination group, n = 39 ）. Education on diabetes, the attention of diets and the control of blood glucose with oral anti-hyperglycemic drug with or without insulin were performed simultaneously in the 3 groups. Results Improvement of DPN symptoms in combined group was significantly better than that of the single ALA group or mecobalamin group. The efficacy rate for numbness was 73.5% ,70.6% and 92.1% respectively in ALA, mecobalam and combination group after 3 weeks therapy （ P 〈 0.05 ）. The efficacy rate for neuralgia was 68. 8% ,72.7% and 91.9% respectively in ALA, mecobalamin and combination group after 3 weeks＇ therapy （ P 〈 0.05）. Conclusion The combined therapy of ALA and mecobalamin is better than each of single drug for improvement of DPN symptoms.

关 键 词：糖尿病外周神经病变 Α-硫辛酸 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]