急性中枢神经系统感染患儿IL-6和TNF-α的变化及临床意义  

The change and clinical significance of IL-6 and TNF-α in children patients with acute central nervous system infection

作　　者：潘雪峰 郑定容[2] 刘志伟[2] 

机构地区：[1]广东省惠州市中心人民医院儿科,广东惠州516001 [2]广东省深圳市宝安区西乡人民医院,广东深圳518102

出　　处：《中国医药导报》2009年第9期30-31,共2页China Medical Herald

摘　　要：目的:研究急性中枢神经系统感染患儿血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的变化及临床意义。方法:采用ELISA法对53例初诊为中枢神经系统感染患儿,其中,化脓性脑膜炎(PM)22例,病毒性脑膜脑炎(VE)31例,进行了血清IL-6和TNF-α水平测定,并与60例正常儿童的测定值进行比较。结果:PM组患儿血清中IL-6和TNF-α水平分别为(636±329)pg/ml和(485±261)pg/ml,明显高于VE组的(175±136)pg/ml和(63±52)pg/ml和对照组的(12±8)pg/ml和(17±13)pg/ml(均P<0.001),VE组血清中IL-6和TNF-α水平亦明显高于对照组(P<0.01和P<0.05)。结论:IL-6和TNF-α参与了急性中枢神经系统感染的病理生理过程,血清中IL-6和TNF-α的测定可能对急性中枢神经系统感染的诊断具有一定的意义。Objective： To study the change and clinical significance of interleukin-6 （IL-6） and tumor necrosis factor-Alpha （TNF-α） in children patients with acute central nervous system infection. Methods： ELISA was employed to detect the level of IL-6 and TNF-α in 53 children patients preliminarily diagnosed as acute central nervous system infection, and 22 patients were purulent meningitis （PM）, 31 patients were viral meningitis （VE） within them. Results： The levels of IL-6 and TNF-α in blood serum of PM group were （636±329） pg/ml and （485±261） pg/ml respectively, significantly higher than that in VE group [（175±136） pg/ml and （63±52） pg/ml respectively] and control group [（12±8） pg/ml and （17±13） pg/ml respectively] （average P〈0.001）. The levels of IL-6 and TNF-α in blood serum of VE group were also obviously higher than that in control group （P〈0.01 and P〈0.05）. Conclusion： IL-6 and TNF-α participate in the pathology physiological process of a- cute central nervous system infection, the detection of the levels of IL-6 and TNF-α in blood serum probably plays a role in diagnosing acute central nervous system infection.

关 键 词：脑膜炎 血清 白细胞介素-6 肿瘤坏死因子 

分 类 号：R512.3[医药卫生—内科学]