铅对海马齿状回L-LTP和双脉冲反应的影响  

Effects of Lead on L-LTP and PPF in Hippocampal Dentate Gyrus

作　　者：阮迪云[1] 陈聚涛[1] 赵望发 柳素玲 顾炜玮 

机构地区：[1]中国科技大学生物系,合肥230027

出　　处：《广东微量元素科学》1998年第4期25-29,共5页Trace Elements Science

基　　金：国家自然科学基金!39630270

摘　　要：应用在位电生理技术研究了发育过程中的铅暴露对成年大白鼠海马齿状回超长时程增强（L－LTP）和双脉冲反应（PPF）的影响。结果表明，铅使海马神经元EPSP和PS诱导的L－LTP幅度降低，维持时间缩短，提示铅可能对形成长期记忆中起关键作用的新蛋白合成过程造成损伤。铅使双脉冲易化幅度降低，易化时间宽度变窄，提示铅主要使突触后NMDA受体造成损伤。The alterations of late long-term potention (L-LTP) and Paired-pulse facilitation (PPF)in hippocampal dentate gyms (DG) in adult rats following developmental lead exposure were studied in vivo by electrophysiological techniques. The results demonstrated that the lead exposure caused a decrese process of L-LTP and lasting time induced by excitatory postsynatic potentiations (EPSPs) and population spikes (PSs). It indicated that lead might impair the synthesis new protein PPF amplitude and the width of PPF wave. It indicated that lead might impair the post-synaptic NMDA receptor.

关 键 词：铅 L-LTP 海马 双脑冲反应 脑损伤 

分 类 号：R595.2[医药卫生—内科学] R742[医药卫生—临床医学]