5-氯-2,3-二氢-2-羟基-1-氧代-1H-茚-2-羧酸甲酯合成研究进展  

Progress in Synthesis of 5-Chloro-1-Oxo-2,3-Dihydroindene-2-Carboxylate

作　　者：朱玉青[1] 余生[1] 胡新根[1] 陈帆[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《辽宁化工》2009年第3期180-184,共5页Liaoning Chemical Industry

摘　　要：综述了5-氯-2,3-二氢-2-羟基-1-氧代-1H-茚-2-羧酸甲酯的各种合成方法。认为研究开发基于手性配体的金属催化剂是提高产品ee值和产率的重要发展途径。The synthesis of the intermediate： （ ＋ ） 5 - chloro - 1 - oxo - 2,3 - dihydroindene - 2 - carboxylate is the key step in the whole synthesis process of the new pesticide indoxacarb. This reaction step produces chiral molecule structure. The enantiomeric excess and insecticidal activity depend upon the asymmetry of the reaction. In this paper, the current progress of the synthesis of （ ＋ ） 5 -chloro -1 -oxo- 2,3 -dihydroindene -2 -carboxylatc have been reviewed. It is considered that the development of metallic catalysts based on polydentate chiral ligands to promote the enantiomefic excess and the yield of the product is a challenging work and an important tendency.

关 键 词：5-氯-2 3-二氢-2-羟基-1-氧代-1H-茚-2-羧酸甲酯 茚虫威 杀虫剂 

分 类 号：S482.3[农业科学—农药学]