氟比洛芬酯对全身麻醉用药量影响的研究  

Effect of pre-operative flurbiprofen on anesthetics dosage during general anesthesia

作　　者：刘春霞[1] 张亚军[1] 贾乃光[1] 

机构地区：[1]中日友好医院麻醉科,北京100029

出　　处：《中日友好医院学报》2009年第1期7-8,12,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨术前使用氟比洛芬酯对全身麻醉用药量的影响。方法:75例接受桥小脑角显微神经血管减压手术的患者随机分成3组,每组25例,术中静脉吸入复合维持麻醉。A组未使用氟比洛芬酯。B组麻醉诱导前静脉注射氟比洛芬酯1mg/kg。C组麻醉诱导前静脉注射氟比洛芬酯2mg/kg。手术中吸入笑气的浓度不变,根据熵指数监测与血流动力学指标变化调节静脉麻醉药用量。记录手术时间、血流动力学指标、异丙酚与雷米芬太尼用量。结果:3组患者的一般情况、手术时间相同。A组患者手术中异丙酚的用量为183.49±29.82mg,雷米芬太尼用量为563.45±9.61μg。B组患者手术中异丙酚的用量为171.18±34.82mg,雷米芬太尼的用量为496.44±69.07μg。C组患者异丙酚的用量为143.2±29.03mg,雷米芬太尼的用量为363.60±51.86μg。与A组相比,C组患者手术中异丙酚与雷米芬太尼用量显著减少(P<0.05)。结论:术前静脉注射氟比洛芬酯1mg/kg对手术中麻醉药用量影响不大。而静脉注射2mg/kg能明显减少手术中麻醉药用量。Objective：To investigate the effect of pre-operative flurbiprofen on anesthetics dosage during general anesthesia.Methods：Seventy-five patients were randomly allocated to 3 groups：Group A（n=25）：no pre-operative flurbiprofen.Group B（n=25）：1mg/kg flurbiprofen i.v.before anesthesia induction.Group C（n=25）：2mg/kg flurbiprofen i.v.before anesthesia induction.Anesthesia induced with propofol and fentanil,maintained with propofol-remifentanil infusion combined with nitrous-oxide inhalation.Nitrous-oxide inhalation concentration was 50%,propofol and remifentanil dosage adjusted according to the hemodynamic parameter and entropy monitoring.Anesthesia time,anesthestics usage and hemodynamic data were recorded.Results：No significant differences were found in age,body mass index and operation duration among the three groups.The mean dosage of propofol and remifentanyl in group A was 183.49±29.82mg and 563.45±9.61μg respectively.The mean dosage of propofol and remifentanyl in group B was 171.18 ±34.82mg and 496.44 ±69.07μg respectively.The mean dosage of propofol and remifentanyl in group C was 143.2±29.03mg and 363.60±51.86μg respectively.Compared with group A,propofol and remifentanyl dosage in group C was obviously reduced（P〈0.05）.Conclusion：Pre-operative flurbiprofen 1mg/kg does not affect the anesthetic dosage,but pre-operative flurbiprofen 2mg/kg can reduce the anesthetics dosage.

关 键 词：氟比洛芬酯 全身麻醉 用药量 

分 类 号：R614[医药卫生—麻醉学]