盐酸马普替林干预治疗冠心病合并抑郁焦虑症临床研究  

Maprotiline Hydrochloride Tables in Treatment of Coronary Heart Disease with Depression Anxiety

作　　者：孙全格[1] 童文玲[1] 黄文[1] 

机构地区：[1]武警山东总队医院,山东省济南市2500014

出　　处：《实用心脑肺血管病杂志》2009年第2期112-113,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察口服盐酸马普替林治疗冠心病合并抑郁焦虑症的临床疗效及安全性。方法我院收治156例冠心病合并抑郁焦虑患者,随机分为对照组和治疗组各78例,治疗组患者应用盐酸马普替林治疗,对照组常规治疗。结果治疗组显效35例,有效34例,无效6例,加重3例,总有效率88.5%;对照组显效22例,有效29例,无效19例,加重8例,总有效率65.4%;两组总有效率间差异有统计学意义(P<0.05)。两组治疗前后心绞痛发作频率、心绞痛持续时间、硝酸甘油用量均显著减少(P<0.05),以治疗组减少更明显(P<0.05)。结论盐酸马普替林是一种有效的治疗冠心病合并抑郁焦虑症的药物。Objective To investigate the efficacy and salty of maprotiline hydrochloride tables in treatment of coronary heart disease with depression anxiety. Methods Seventy - eight coronary heart disease patients with depression anxiety took 50mg maprotiline hydrochloride tables for four weeks. Results （ 1 ） The total effective rate on angina of the treatment group was 88. 5%, significantly higher than that of the control group （65.4%）. （2） Compared with control group treatment group showed a significant fall in HAMD. Conclusion Maprotiline hydrochloride tables is efficacious and safe of coronary heart disease with depression anxiety.

关 键 词：盐酸马普替林 冠状动脉疾病 抑郁 

分 类 号：R541.4[医药卫生—心血管疾病]