无环鸟苷-干扰素治疗单疱病毒性角膜炎疗效观察  

The clinical effect of acyclovir combined with interferon on herpes simplex keratitis (HSK)

作　　者：黄振伟 吴泽峰 黄梓材[3] 

机构地区：[1]汕头市医学科学研究所,广东汕头515031 [2]汕头市濠江区人民医院,广东汕头515071 [3]汕头市中心医院,广东汕头515031

出　　处：《中国热带医学》2009年第4期686-686,695,共2页China Tropical Medicine

摘　　要：目的研究无环鸟苷-干扰素联合治疗单纯疱疹病毒性角膜炎(HSK)的临床疗效。方法65例单纯疱疹毒性角膜炎患者随机分为治疗组36例和对照组29例,治疗组以0.1%无环鸟苷与重组人a-干扰素(冻干粉剂)制成的混合滴眼液治疗,对照组以0.1%无环鸟苷滴眼液及环胞苷滴眼液治疗。结果治疗组36例中33例治愈,治愈率91.6%,平均治愈天数30.4d;对照组29例中25例治愈,治愈率89.7%,平均治愈天数39.6d;无环鸟苷-干扰素组同对照组比较治愈率大致相同,无显著性差异,疗程无环鸟苷-干扰素组明显缩短(P<0.05)。结论无环鸟苷-干扰素联合眼药水治疗HSK,疗效确切,无不良反应,有推广价值。Objective To study the clinical effect of acyclovir combined with interferon on herpes simplex keratitis （HSK）. Methods 0.1% acyclovir and recombinant human interferon α eye mixed drops were prepared and used to treat HSK. Results There 33 out of the 36 patients in treatment group, were cured （91.6%）, the average date of recoveryg was 30.4 days, 26 out of the 29 patients in cnntrol group were cured, with the cure rate of 91.6 and 89.7% in the control group. The average date of healing was 39.6 days, there was not significant difference between treatment group and control group , but the course of treatment in reatment group was significant shotrer than than in control group （P〈0.05）. Conclusion The clinical effect of acyclovir combined with interferon is definite on herpes simplex keratitis （HSK） without adverse reaction and worthy of popularization.

关 键 词：干扰素 无环鸟苷眼药水 单纯疱疹病毒性角膜炎 

分 类 号：R772.21[医药卫生—眼科]