Lipin：治疗胰岛素抵抗的新靶点  

Lipin ： a new useful target in the treatment of insulin resistance

作　　者：江华[1] 尹士男[1] 

机构地区：[1]解放军总医院第一附属医院内分泌科,北京100037

出　　处：《国际内分泌代谢杂志》2009年第2期110-112,116,共4页International Journal of Endocrinology and Metabolism

摘　　要：脂素基因（LPIN）是新近发现的双向调控身体脂肪的一个基因家族，至少包括LPIN1，LPIN2，LPIN3 3个成员。其蛋白产物称为脂素（lipin）。该蛋白家族在不同组织发挥相似的功能，主要有两个作用：一是作为磷脂酸磷酸酶（PAP）1发挥甘油三酯、磷脂合成作用，二是作为转录协同刺激因子联系肝过氧化物酶体增殖物活化受体（PPAR）γ协同刺激因子1α（PGC1α）和PPARα，进而调节脂肪酸氧化基因的表达，因而在脂质合成和基因表达方面有双重作用，影响着糖脂代谢。该基因变异可能与胰岛素抵抗、肥胖、2型糖尿病及代谢综合征相关。Lipin可能为胰岛素抵抗、肥胖、糖尿病及其相关代谢异常提供新的治疗靶点。LPIN is a gene family identified recently that can induce extreme states of adiposity. The gene family includes at least three members LPIN 1, LPIN 2 and LPIN 3. The proteins that they encode are named lipin, which carry out similar functions in different tissues. Members of the lipin protein family as a phosphatidate phosphatase play a role in the biosynthesis of triglyceride and phospholipid, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor γ （PPAR γ） coactivator-1α and PPAR α that modulates the expression of fatty acid oxidation gene. So they have dual roles in lipid biosynthesis and gene expression, therefore influencing lipid metabolism and glucose homeostasis. Mutations in LPIN may be associated with insulin resistance, obesity, type 2 diabetes mellitus and metabolic syndrome. Lipin may be a new useful target in treatment of insulin resistance.

关 键 词：胰岛素抵抗 糖尿病 LIPIN 

分 类 号：R587[医药卫生—内分泌]