姜黄素与DNA相互作用的电化学性质  

Electrochemical Studies of Interaction Between Curcumin and DNA

作　　者：张亚锋 吴萍 林新华[3] 

机构地区：[1]西安市药品检验所,陕西西安710075 [2]常州市人民医院,江苏常州213003 [3]福建医科大学药学院,福建福州310004

出　　处：《化学研究》2009年第1期37-39,共3页Chemical Research

基　　金：国家自然科学基金资助项目(20675015)

摘　　要：采用循环伏安法和差示脉冲伏安法,研究了姜黄素在DNA修饰玻碳电极上与DNA的相互作用.结果表明,姜黄素与DNA之间发生嵌插作用,形成了两种化合物DNA-2curcumin和DNA-curcumin,两者的表观结合常数分别为2.34×105L/mol和1.48 L/mol.The interaction between curcumin and DNA were investigated try and differential pulse voltammetry with DNA-modified glassy carbon that the interaction mode is intercalation at pH 4.0 tris-HCl buffer. Two and DNA, DNA-2curcumin and DNA-curcumin, are formed with bindin tool and 1.48 L/tool, respectively. by means of cyclic vohammeelectrodes. The results show kinds complexes of curcumin g constants of 2.34 ×10^5 L/

关 键 词：姜黄素 小牛胸腺DNA 循环伏安法 差示脉冲伏安法 DNA修饰玻碳电极 

分 类 号：O657.1[理学—分析化学]