基于LARS算法的川芎成分组合与血管活性关系分析  

Association between Rhizoma Chuanxiong Constituents Combinations and Vasodilatation Activity Based on Least Angle Regression Algorithm

作　　者：李振坤[1,2] 陈建新[3,4] 杨洪军[2] 刘玫琦[2] 黄璐琦[2] 易建强[4] 

机构地区：[1]江西中医学院,江西南昌330004 [2]中国中医科学院中药研究所,北京100700 [3]北京中医药大学,北京100029 [4]中国科学院自动化研究所,北京100190

出　　处：《中国实验方剂学杂志》2009年第3期24-27,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金(30600820);国家重点基础研究发展计划(2006CB504700)

摘　　要：目的:探索适合中药"组效关系"的分析方法。方法与结果:以川芎为范例,基于LARS算法,按照均匀试验设计-药效试验-数学建模(模型验证)程序,得到阿魏酸、丁基苯酞、藁本内酯3种成分不同组合与血管活性的关系,实现了成分组合的活性优化。结论:LARS算法是中药"组效关系"研究的有效方法之一。Objective： To investigate the method of constituent-activity relationship suitable for Chinese herbs. Methods and Results： Rhizoma chuanxiong is set as a paradigm, based on the least angle regression algorithm, we find the association between the vasodilatation activity and the different concentration combination of ferulic acid, butylphthalide and ligustilide, according to the scheme of Uniform Experimental Design-Efficacy Experiment mathematical modeling （model validation ）. We also optimize the different concentration combination of the three constituents. Conclusion： Least angle regression algorithm is an effective method for research of constituent-activity relationship of Chinese herbs.

关 键 词：LARS算法 组效关系 川芎 

分 类 号：R114[医药卫生—卫生毒理学] R473.6[医药卫生—公共卫生与预防医学]