疏肝益肾方对38例激素依赖性晚期乳腺癌的临床研究  

Clinical Study on Estrogen-dependent Advanced Breast Cancer Treated by Shuganyishen Prescription

作　　者：卢雯平[1] 张培彤[1] 陈丽珠[1] 陈艳斌[1] 刘浩[1] 石闻光[1] 闫洪飞[1] 林洪生[1] 樊岚岚[2] 

机构地区：[1]中国医学科学院广安门医院肿瘤科,北京100053 [2]中医古籍出版社,北京100700

出　　处：《中国实验方剂学杂志》2009年第3期73-75,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中国中医科学院第二批优势病种(项目编号CACMS07Y0015)

摘　　要：目的:观察疏肝益肾方联合西医对激素依赖性晚期乳腺癌患者的临床疗效,从对激素影响角度探讨其机制。方法:用疏肝益肾方联合西医治疗共观察了38例内脏或脑转移的激素受体阳性的晚期乳腺癌患者,疏肝益肾方,每日1剂,服药至少半年;西医按照NCCN(National comprehensive cancer network)指南给予相应的治疗。结果:转移后中位生存期为34.08个月,中位肿瘤进展时间(time to progress TTP)为9.6个月。1、2年生存率分别为92%、62.5%。肝转移患者平均生存时间为20.48个月,中位生存时间为20个月;肺转移患者的平均生存时间为44.47个月,中位生存为52个月;两个部位转移的平均生存时间为8个月,中位生存时间为11个月;降低了雌二醇(E2),提高了促卵泡生成激素(FSH)。患者潮热汗出服药后好转率为70.1%(27/38)。结论:疏肝益肾方治疗激素依赖性的晚期乳腺癌疗效好,可改善潮热症状,机理可能与对E2的抑制及富含植物雌激素的疏肝益肾方对ERβ的作用有关。Objective：To observe the clinical effect of Shuganyishen prescriptipn combined with western therapy on estrogen-dependent advanced breast cancer, and to investigate the mechanism from the angle of affecting hormone. Method： A total of 38 patients with visceral or brain metastasis were administered with Shuganyishen prescription combined with western treatment, shuganyishen prescription＇s dosage was 200 mL, twice a day, and west medicine treament regimen was administered by NCCN guideline. Results： The median survival of recurrence（MSR） was 34.08 months, time to progress was 9.6 months, one and two year survival rates were 92% ,62.5% respectively, mean and median survival times with liver metastasis were 20.48 months and 20 months respectively. Mean and median survival times with lung metastasis were 44.47 months and 52 months respectively. Mean and median survival times with both liver and lung metastasis were 44.47 months and 52 months respectively. Mean and median survival times with both liver and lung metasis were 8 months and 11 months respectively. It decreased E2 and, improved follicle-stimulating hormone （FSH）. The remission rate of red flash symptom was 70.1%. Conclusion： Shuganyishen prescription had good clinical effect to estrogen-dependent advanced breast cancer, and relieved red flash symptom. The mechanism might be that the prescription inhibited E2 and the phytoestrogens in the herbs had effect on ERβ.

关 键 词：疏肝益肾方 激素依赖性晚期乳腺癌 临床研究 

分 类 号：R285.6[医药卫生—中药学]