子宫内膜异位症患者血清对氧磷脂酶-1的测定及临床意义  

The role of PON-1 and MDA in the serum of patients with endometriosis

作　　者：张艳[1] 马丽丽[2] 李其荣[3] 

机构地区：[1]潍坊医学院,山东潍坊261041 [2]潍坊市人民医院妇科,山东潍坊261042 [3]济南市妇幼保健院,山东济南250001

出　　处：《中国优生与遗传杂志》2009年第3期27-28,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨子宫内膜异位症(内异症)患者血清对氧磷脂酶-1(PON-1)、丙二醛(MDA)水平的变化及其在内异症发病中的作用。方法测定45例内异症患者和20例对照组血清PON-1、MDA的含量,分析PON-1活性与内异症的关系。结果内异症患者血清PON-1水平显著低于对照组(P<0.01),而MDA水平高于对照组(P<0.05),差异有统计学意义。内异症患者PON-1水平重度组明显低于轻度组(P<0.05),其血清水平与病情程度成负相关(r=-0.544,P<0.01)。结论内异症患者PON-1水平明显升高,并随疾病的严重程度而降低,可能在内异症的发生发展中发挥重要作用。Objective ： To investigate the PON - 1 and MDA levels in serum from patients with endometriosis and its role or pathogenesis of endometriosis. Methods： Testing the levels of PON - 1 and MDA from 45 patients （test group） with endometriosis and 20 patients without endometriosis （control group）. Results： The PON - 1 levels in serum were significantly lower in test group than those in control group （ P 〈 0. 01 ）. However, the MDA levels in serum were significantly higher in test group than those in control group （ P 〈 0.05 ）. The PON - 1 levels in serum of the patients with mild endometriosis were significantly higher than those in severe patients （ P 〈0. 05）. There was negative correlation between the PON - 1 levels in serum and the severity of stages （ r = -0. 544, P 〈 0. 01 ）. Conclusions： The results suggest that PON - 1 levels increase in serum from patients with endometriosis, but have an inverse correlation with the extent of endometriosis. The changes of PON - 1 levels in serum may play a role in the pathogenesis of endometriosis.

关 键 词：PON-1 MDA 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]