早孕期孕妇糖化血红蛋白水平与胎儿畸形的关系  

Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in offspring of diabetic mothers

作　　者：李坚[1] 李芳[1] 黄兆明[1] 谢杏梅[1] 钟惠珠[1] 李东至[1] 

机构地区：[1]广州市妇婴医院优生围产研究所生化室,510180

出　　处：《中国优生与遗传杂志》2009年第3期105-105,125,共2页Chinese Journal of Birth Health & Heredity

基　　金：广州市卫生局一般项目(项目编号:2005-YB-185)

摘　　要：目的探讨早孕期孕妇糖化血红蛋白（GHb）水平与胎儿畸形的关系。方法以来我院早孕门诊孕周小于16w，有糖尿病家族史或糖尿病史的孕妇126例为对象，用高效液相色谱仪（HPLC）测定HbAlc，孕20～24w进行彩色B超检查。B超未发现异常的胎儿继续妊娠，追踪观察至胎儿娩出，分析HbAlc水平与胎儿畸形的相关性。结果早孕期HbAlc水平大于11％时，胎儿畸形发生率明显升高。Objective： To evaluate hemoglobin A1 c （HbAlc） for predicting congenital abnormalities in overt diabetic pregnancies. Methods： Overt diabetic gravidas with initial hemoglobin A1 c （ HbA1 c） above 6. 5%, or a family history of congenital heart disease were referred to detailed fetal sonography and follow -up. Totally, 126 patients received care in the diabetes and pregnancy service . Results： An initial HbAlc above 11% was highly associated with fetal abnormalities. Conclusions： Among patients with abnormal HbAlc values, detailed fetal examination was recommended.

关 键 词：早孕期 糖化血红蛋白 胎儿畸形 

分 类 号：R714.2[医药卫生—妇产科学]