尿路感染产超广谱β-内酰胺酶菌的耐药性及危险因素分析  

Antimicrobial resistance and risk factors of ESBLs-producing strains in urinary tract infection

作　　者：张希燕[1] 肖青[1] 陶元勇[1] 陈静[1] 范秀芳[1] 张雪梅[1] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261042

出　　处：《检验医学与临床》2009年第6期404-406,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨尿路感染产超广谱β-内酰胺酶(ESBLs)菌株的耐药性及其危险因素。方法选取尿培养结果为革兰阴性杆菌的患者168例,其中产ESBLs菌尿路感染患者63例为观察组,非产ESBLs菌尿路感染患者105例为对照组,对两组尿路感染细菌的耐药性进行比较,并采用Logistic回归分析产ESBLs菌株致尿路感染的危险因素。结果产ESBLs组对头孢菌素等多种抗菌药物的耐药性显著高于非产ESBLs组,差异有统计学意义(均P<0.01);第3代头孢菌素的使用和留置尿管等是产ESBLs菌致尿路感染的独立危险因素(相关危险度值分别为15.121和8.847)。结论产ESBLs菌株耐药性严重,临床上应采取有效措施加以防控。Objective To explore antimicrobial resistance and risk factors of extended spectrum β-lactamases （ESBLs）-producing strains in urinary tract infection （UTI）. Methods Totally 168 patients who were urine gram negative bacilli positive were individed into observation group （n = 63, ESBLs-producing group） and control group （n = 105,ESBLs non-producing group）. The drug resistant spectrum was compared between two groups, while logistic regression analysis was adopted to investigate the clinical risk factors of UTI caused by ESBLs-producing strains. Results The resistant rates of ESBLs-produeing strains to some antibiotics were significant higher than those of non- ESBLs-producing ones （P〈0.01）. Use of the third generation cephalosporins and detaining of urinary canal were the independent risk factors of UTI caused by ESBLs-producing strains （OR = 15. 121,OR= 8. 847）. Conclusion The state of antimicrobial resistance of ESBLs-producing strains is serious. Some measures should be taken to prevent and control the spread and transmission of ESBLs-producing strains.

关 键 词：尿路感染 超广谱Β-内酰胺酶 细菌抗药性 危险因素 

分 类 号：R695[医药卫生—泌尿科学] R969.3[医药卫生—外科学]