嗜麦芽窄食单胞菌两时段药敏测定及分析  

Analysis on antimicrobial resistance of Stenotrophomonas maltophilia clinical isolates at two timepoints

作　　者：李艳萍[1] 杨玉玲[2] 李丰良[3] 刘海云[3] 杜廷义[3] 曾光雄[3] 

机构地区：[1]云南省红河州第二人民医院检验科,654300 [2]云南省江川县人民医院检验科 [3]云南省第一人民医院检验科

出　　处：《检验医学与临床》2009年第6期423-424,共2页Laboratory Medicine and Clinic

摘　　要：目的了解嗜麦芽窄食单胞菌(SMA)两时段对抗菌药物的耐药情况,为临床治疗及用药提供参考依据。方法对临床分离的69株SMA,用API和VITEK鉴定系统进行鉴定,以纸片琼脂扩散(K-B)法检测SMA24h和48h对10种抗菌药物的敏感性。结果69株SMA24h对10种抗菌药物的敏感性由高到低为:左氧氟沙星87.0%,复方新诺明84.1%,替卡西林/棒酸84.1%,头孢哌酮/舒巴坦78.3%,奈替米星56.5%,头孢他啶55.1%,阿米卡星43.5%,头孢吡肟29.0%,哌拉西林13.0%,哌拉西林/他唑巴坦10.1%,亚胺培南0.0%;48h依次为:左氧氟沙星79.7%,替卡西林/棒酸78.3%,头孢哌酮/舒巴坦65.2%,奈替米星47.8%,头孢他啶40.6%,阿米卡星31.9%,头孢吡肟13.0%,哌拉西林/他唑巴坦13.0%,哌拉西林5.8%,复方新诺明5.8%、亚胺培南0.0%。结论对SMA感染患者应重视48h药敏测定,并选择左氧氟沙星或替卡西林/棒酸进行治疗。复方新诺明治疗SMA疗效不理想。Objective To investigate the antimicrobial resistance status of Stenotrophomonas maltophilia （SMA） clinical isolates at two timepoints, so as to offer basis for clinical medication. Methods Totally 69 clinical isolates of Stenotrophomonas maltophilia were isolated from various clinical specimens, and identified with API and VITEK identification system. K-B method was used to test the antimicrobial susceptibility of 10 kinds of antihacterials against SMA at 24 th and 48 th timepoints. Results The antimicrobial susceptibility of 10 kinds of antibacterials against SMA isolates at 24 th timepoint in order was as follows., levofloxacin 87.0%, SMZ-TMP 84.1%, ticarcillin/ clavulanic acid 84.1%, cefoperazone/sulbaetam 78.3 %, netilmicin 56.5 %, eeftazidime 55. 1%, amikacin 43.5 %, cefepime 29.0%, piperacillin 13. 0%, piperacillin/tazobactam 10. 1%, imipenem 0.0% ; at 48 th timepoint： levofloxacin 79.7%, ticarcillin/clavulanic acid 78. 3%, cefoperazone/sulbactam 65.2%, netilmicin 47.8%, ceftazidime 40.6%, amikacin 31. 9%, cefepime 13.0%, piperaeillin/tazobactam 13.0%, piperacillin 5.8%, SMZ-TMP 5.80%, imipenem 0.0%. Conclusion It is necessary to perform antimicrobial susceptibility test at 48 h timepoint for SMA infection. It suggests that levofloxacin or ticarcillin/clavulanic acid be used to treat SMA infection. The curative effect of SMZ-TMP is dissatisfactory.

关 键 词：嗜麦芽窄食单胞菌 交叉感染 微生物敏感性试验 

分 类 号：R446.5[医药卫生—诊断学] R969.4[医药卫生—临床医学]