三(3,6-二氧杂庚基)胺相转移催化合成Rothindin  

Synthesis of rothindin in the presence of tri(3,6-dioxaheptyl)amine

作　　者：雷英杰[1] 杨亮[1] 刘福德[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《化学研究与应用》2009年第3期393-395,共3页Chemical Research and Application

基　　金：天津理工大学资助项目(601002001)

摘　　要：A reaction for the synthesis of rothindin,a naturally occurring isoflavone glycoside,between the 7-hydroxy-3′,4′-methylenedioxyisoflavone(ψ-baptigenin),which are prepared in good yield from a Houben-Hoesch reaction,and 1-bromo-2,3,4,6-tetra-O-acetyl——D-glucopyranose at the NaHCO3/KCl alkaline solutions in presence of the phase transfer catalyst tri(3,6-dioxaheptyl)amine(TDA-1) is discussed.The formation of the corresponding glucosides are confirmed by IR and 1HNMR studies,with a 82% yield of O-glycoside conjugate.A reaction for the synthesis of rothindin, a naturally occurring isoflavone glycoside, between the 7-hydroxy-3＇, 4＇- methylenedioxyisoflavone （ψ- baptigenin） ,which are prepared in good yield from a Houben-Hoesch reaction,and 1-bromo-2,3,4, 6-tetra-O-acetyl- -D-glucopyranose at the NaHCO3/KCl alkaline solutions in presence of the phase transfer catalyst tri （3,6- dioxaheptyl） amine （ TDA-1 ） is discussed. The formation of the corresponding glucosides are confirmed by IR and ^1HNMR studies, with a 82% yield of O-glycoside conjugate.

关 键 词：异黄酮糖苷 Rothindin 合成 三(3 6-二氧杂庚基)胺 

分 类 号：O629.9[理学—有机化学]