含四氢噻吩类生物素杂质的合成  

Synthesis of d-biotin impurity with tetrahydrothiophen compound

作　　者：陈建辉[1,2] 潘一斌[2] 陈浙蓉[2] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009 [2]浙江医药股份有限公司新昌制药厂,浙江新昌312500

出　　处：《化学研究与应用》2009年第3期416-418,共3页Chemical Research and Application

基　　金：国家科技兴贸行动专项(2006GH553302)资助项目;浙江省重大科技专项(2006C11190)资助项目

摘　　要：Three new impurities of d-Biotin were synthesized:(2S,3S,4S)-5-(3,4-diamino-tetrahydro-thiophen-2-yl)-pentanoic acid,(3aS,4S,6aR)-hexahydro-1-thia-3,4a-diaza-cyclopenta inden-4-one and(3aS,4S,6aR)-4-(5’-Oxo-hexyl)-tetrahydro-thieno-imidazol-2-one.Structures of target compounds were confirmed by NMR and so on.Our work further improved the research on the impurities of d-biotin,and can be applied to the quality control and quality assurance of d-biotin.Three new impurities of d-Biotin were synthesized： （ 2S, 3 S, 4S ） -5- （ 3,4 -diamino- tetrahydro -thiophen-2 -yl ） -pentanoie acid, （3aS,4S, 6aR） -hexahydro-1 -thia-3,4a-diaza-cyclopenta [ cd ] i nden-4-one and （3 aS,4S,6aR） -4- （5＇ -Oxo-hexyl ） -tetrahydro-thieno-[3,6] imidazol-2-one. Structures of target compounds were confirmed by NMR and so on. Our work further improved the research on the impurities of d-biotin, and can be applied to the quality control and quality assurance of d-biotin.

关 键 词：生物素 有关物质 四氢噻吩 合成 

分 类 号：O626.12[理学—有机化学]