艾托拉嗪的合成  

The synthesis of eltoprazine

作　　者：李春明[1] 林原斌[1] 张耕[1] 林彦飞 

机构地区：[1]湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105

出　　处：《化学研究与应用》2009年第3期419-422,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目(No.30470388)

摘　　要：A new method for synthesizing eltoprazine is presented in this article.3-nitrobenzene-1,2-diol is synthesized with pyrocatechol via a nitrating reaction,and then we use 1,2-dibromoethane as the cycling agent to prepare 5-nitro-2,3-dihydrobenzo[b]dioxine.5-amino-2,3-dihydrobenzo[b]dioxine is synthesized with 5-nitro-2,3-dihydrobenzo[b]dioxine via a reductive reaction in ethanol using hydrazine hydrate as reductive agent and Pd/C as catalyst.The object product eltoprazine is then prepared by a cycling reaction using bis(2-chloroethyl)ammonium chloride.This method could be easy to operate in laboratory and get a high yield.A new method for synthesizing ehoprazine is presented in this article. 3- nitrobenzene-1,2-diol is synthesized with pyrocatechol via a nitrating reaction, and then we use 1,2-dibromoethane as the cycling agent to prepare 5-nitro-2,3-dihydrobenzo [ b ] [ 1,4] dioxine. 5-amino-2,3-dihydrobenzo[ b] [ 1,4 ] dioxine is synthesized with 5-nitro-2,3-dihydrobenzo [ b ] [ 1,4 ] dioxine via a reductive reaction in ethanol using hydrazine hydrate as reductive agent and Pd/C as catalyst. The object product ehoprazine is then prepared by a cycling reaction using bis （2-chloroethyl）ammonium chloride. This method could be easy to operate in laboratory and get a high yield.

关 键 词：3-硝基邻苯二酚 艾托拉嗪 合成 

分 类 号：O625.11[理学—有机化学]