HBV感染研究中Th细胞分化的调节和意义  

Regulation and Significance of the Th Cells Differentiation in HBV Infection Research

作　　者：薛源[1] 韦嘉[1] 

机构地区：[1]昆明医学院第一附属医院感染科

出　　处：《医学综述》2009年第6期813-816,共4页Medical Recapitulate

摘　　要：Th细胞免疫失衡是乙型肝炎病毒（HBV）慢性感染的重要机制之一。Th细胞分化受细胞因子及其受体、T细胞受体（TCR）-抗原提呈细胞（APC）-抗原／主要组织相容性复合物、细胞信号转导、HBV基因型及变异、调节性T细胞（Treg）等方面的影响。了解Th细胞分化情况，对HBV感染的防治有重要指导意义。一是有助于了解乙型肝炎疫苗的接种效果和改进疫苗；二是指导研发抗病毒药物和治疗性疫苗，通过上调Th1免疫反应或调节Th2优势反应向Th1优势反应转化来治疗慢性乙型肝炎。The immune imbalance of T helper （Th） cells is an important pathogenesis of hepatitis B virus （HBV） infection. The differentiation of Th cells is regulated by cytokines and their receptors,T cell receptor（TCR） -antigen presenting cells（ APC ） -antigen/major histocompatibility complex, cell signal transduction, genotypes and variation of HBV, regulatory T cells（ Treg）. Understanding the differentiation of Th cells has important directive significance to the prevention and treatment of HBV infection. First,it will help us to understand the effectiveness of hepatitis B vaccines and improve the vaccines ; The second is to guide the research of antiviral drugs and therapeutic vaccines,to treat chronic hepatitis B by up-regulating Th1 immune response or adjusting Th2 predominant response to the Thl response.

关 键 词：TH细胞 乙型肝炎病毒 TH1型细胞因子 TH2型细胞因子 

分 类 号：R512.62[医药卫生—内科学]