心肌重构过程中基质金属蛋白酶系统的调节及分子生物学机制  

Regulation of Matrix Metalloproteinases During Myocardial Remodeling and the Molecular Biological Mechanism

作　　者：陈强[1] 黄石安[1] 陈灿[1] 

机构地区：[1]广东医学院附属医院心内科二区

出　　处：《医学综述》2009年第6期835-838,共4页Medical Recapitulate

摘　　要：心肌重构与多种心血管疾病的发生、发展密切相关，是一种复杂的病理过程，其发病机制迄今尚未完全阐明。基质金属蛋白酶家族是其中一个重要的影响因素，其表达主要受一系列神经内分泌因素、细胞因子、活性氧等因素的影响。现就心肌重构过程中影响基质金属蛋白酶表达的因素及其可能的分子生物学机制予以综述。Myocardial remodeling is closely related to the development of multiple cardiovascular diseases,with complex pathophysiology and elusive pathogenesis. The matrixmetalloproteinases may be one of the critical elements during the process, is mainly influenced by neuroendocrine, cytokine and active oxygen. Now the regulatory factors of matrix metalloproteinases during myocardial remodeling and the molecular biological mechanism will be discussed.

关 键 词：心肌重构 基质金属蛋白酶 分子生物学机制 

分 类 号：R542.2[医药卫生—心血管疾病]