转化生长因子β1基因多态性与心血管疾病相关性的研究  

Association of Transforming Growth Factor β1 Gene Polymorphism with Cardiovascular Disease

作　　者：赵丹[1] 钟华[1] 何芳[1] 

机构地区：[1]新疆地方病与民族高发病省部共建教育部重点实验室,石河子大学医学院病理生理学教研室

出　　处：《医学综述》2009年第7期966-968,共3页Medical Recapitulate

基　　金：国家自然科学基金(30760077);兵团博士基金(2007JC13)

摘　　要：心血管疾病是危害各国人民健康的主要疾病，其发病率在我国呈逐年升高趋势，已成为我国慢性非传染性疾病的防治重点。转化生长因子β1基因多态性能影响TGF-β1基因的转录、翻译，并导致TGF-β1血浆水平的变化，进而介导了心血管疾病的发生、发展。本文综述了近年来TGF-β1基因多态性与高血压、心肌梗死、冠状动脉粥样硬化性心脏病等心血管疾病相关性的研究。Cardiovascular disease is the principal disease which is harmful to people＇s healthy,the inci- dence is higher year by year. Cardiovascular disease becomes the prevention and cure＇s focal point of non-in-fectious disease. The gene polymorphisms of transforming growth factorβ1 （TGF-β1）can influence the transcription and translation of the gene TGF-β1 ,which can change the blood level of TGFβ1 ,and then mediate the development of cardiovascular disease. This article summarizes the association of transforming growth fac-tor-betal gene polymorphisms with cardiovascular disease, such as hypertension,myocardial infarction,coronary heart disease and so on.

关 键 词：转化生长因子Β1 基因多态性 高血压 心肌梗死 冠状动脉粥样硬化性心脏病 

分 类 号：R363[医药卫生—病理学]