超极化激活环核苷酸门控的阳离子通道与疾病关系的研究进展  

Study Progress in the Relationship between Hyperpolarization Activated Cyclic Nucleotide Gated Cation Channel and Diseases

作　　者：刘翠英[1] 林春[1] 

机构地区：[1]福建医科大学基础医学院疼痛研究室,生理与病理生理学系,神经生物学研究中心

出　　处：《医学综述》2009年第7期972-974,共3页Medical Recapitulate

基　　金：福建省自然科学基金(C0510011);福建医科大学教授基金(JS07004)

摘　　要：随着对超极化激活电流和超极化激活环核苷酸门控的阳离子通道研究的不断深入，人们对超极化激活电流特性和超极化激活环核苷酸门控的阳离子通道的结构特征、调节、分布有了进一步的了解。近年来，发现除心律失常之外，超极化激活电流异常和超极化激活环核苷酸门控的阳离子通道的机能障碍还与其他多种疾病有关。本文就超极化激活电流特性、超极化激活环核苷酸门控的阳离子通道的特点及二者功能异常与疼痛等神经系统疾病关系的最新研究进展予以综述。With the study of funny current and hyperpolarization activated cyclic nucleotide gated cation channel deepened,people can further know about the character of funny current and the structural feature, regulation,distribution of hyperpolarization activated cyclic nucleotide gated cation channel. Recently, it has been found that the relationship between abnormal funny current or dysfunction of hyperpolarization activated cyclic nucleotide gated cation channel and some diseases besides arrhythmia. The author reviews the latest progresses about the character of funny current and hyperpolarization activated cyclic nucleotide gated cation channel and the relationship between their dysfunction and diseases such as pain in the paper.

关 键 词：超极化激活环核苷酸门控的阳离子通道 超极化激活电流 疾病 

分 类 号：R441.1[医药卫生—诊断学] R742.1[医药卫生—临床医学]