哮喘中干细胞因子与嗜酸粒细胞相关研究进展  

Research Advantage on Relationship between Stem Cell Factor and Eosinophils in Asthma

作　　者：胡斯明[1] 罗雅玲[1] 

机构地区：[1]南方医科大学附属南方医院呼吸内科

出　　处：《医学综述》2009年第7期975-977,共3页Medical Recapitulate

摘　　要：干细胞因子（SCF）是一种新型多功能细胞因子，以可溶型和膜结合型两种形式存在，通过与其酪氨酸激酶受体c-kit结合发挥其生物学作用。SCF及其受体c-kit在肺组织细胞中表达广泛。不仅是肥大细胞重要的活化与趋化因子，而且对嗜酸粒细胞的分化、增殖、活化、趋化过程起重要作用，参与支气管哮喘的气道慢性炎症和气道高反应性过程。深入研究SCF对嗜酸粒细胞的调控作用及机制对哮喘的防治有重要意义。Stem cell factor （SCF） is a new type of multi-functional cytokine with two forms of soluble and membrane-bound, combined with its tyrosine kinase receptor c-kit educe its biology role. SCF and c-kit receptor express widly in the lung tissue cells,which are not only important mast ceil activation and chemotactic factor, but also play an important role for the eosinophil differentiation, proliferation, activation, chemo-kines, participate in chronic airway inflammation of bronchial asthma and airway hyperresponsiveness process. Depth study of SCF to control eosinophils has great significance to prevent asthma.

关 键 词：哮喘 干细胞因子 嗜酸粒细胞 

分 类 号：R562.25[医药卫生—呼吸系统]