早产儿胃肠道外营养相关性肝胆并发症临床观察  

Clinical observation on parenteral nutrition associated liver complication in premature infants

作　　者：钱芳[1] 赵银兰[1] 徐素玲[1] 

机构地区：[1]暨南大学第三附属医院.珠海市人民医院儿科,广东珠海519000

出　　处：《中国妇幼保健》2009年第7期915-917,共3页Maternal and Child Health Care of China

基　　金：珠海市科技计划项目(珠科[2007]47号)

摘　　要：目的:观察胃肠道外营养(PN)早产儿肝胆并发症的发生率,探讨早期敏感的实验室诊断指标。方法:分析113例早产儿PN相关性胆汁淤积(PNAC)的发生情况及PNAC相关的实验室指标,并比较各项指标在PNAC组与无PNAC组间的差别。结果:PNAC的发生率为13.3%。PN后1周血清谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、结合胆红素(DBIL)及总胆汁酸(TBA)两组比较无显著性差异(P>0.05);PN后2周PNAC组ALP、DBIL及TBA明显高于无PNAC组,两组比较有显著性差异(P<0.05)。结论:目前使用的PN方法仍存在着影响早产儿肝胆系统功能的情况;动态监测ALP、DBIL及TBA,有助于早期发现PNAC。Objective:To observe the incidence of parenteral nutrition(PN) associated liver complication in premature infants,explore the early laboratory indexes of diagnosis.Methods:Incidence and laboratory data of parenteral nutrition associated cholestasis(PNAC) in 113 premature infants were analysed and compared between PNAC group and non-PNAC group.Results:Incidence of PNAC in premature infants was 13.3%.There was no significant difference in serum alanine aminotransferase(ALT),alkaline phosphatase(ALP),conjugated bilirubin(DBIL) and total bile acide(TBA) between two groups on 1 week after PN(P>0.05).ALP,DBIL and TBA of PNAC group were higher than those of non-PNAC group on 2 week after PN(P<0.05).Conclusion:PN cann affects the liver function of premature infants at present.Regular monitoring of ALP,DBIL and TBA will be helpful to discover PNAC earlier.

关 键 词：早产儿 胃肠道外营养 并发症 

分 类 号：R722[医药卫生—儿科]