3-(2-氯吡啶-3-基)-2-[4-(2，6-二氟苯基)噻唑-2-基]-3-羟基丙烯腈衍生物的合成及生物活性  

Synthesis and biological activities of 3-(2-chloropyridin-3-yl)-2-(4-(2,6-difluorophenyl)thiazol-2-yl)-3-hydroxyacrylonitrile derivatives

作　　者：杨鹏[1] 沈德隆[1] 谭成侠[1] 翁建全[1] 陆棋[1] 魏优昌[2] 孔小林[2] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032 [2]浙江省化工研究院,浙江杭州310023

出　　处：《浙江大学学报（理学版）》2009年第2期183-185,190,共4页Journal of Zhejiang University（Science Edition）

基　　金：“十一五”支撑计划课题“农药先导结构的创新与优化研究”,项目编号2006BAE01A01-7

摘　　要：鉴于噻唑丙烯腈和吡啶两类化合物的优点,本文以丙二腈、2,6-二氟苯乙酮、2-氯吡啶酸为起始原料,经五步反应,设计合成了3个新的3-(2-氯吡啶-3-基)-2-[[4-(2,6-二氟苯基)噻唑-2-基]-3-取代丙烯腈类化合物;并利用1HNMR、IR、MS,元素分析对其结构进行了表征.初步生物活性测试结果表明:3个化合物在测试浓度下均具有一定杀菌杀虫活性.Based on good biological activities of thiazolylacrylonitrile compounds and pyridine compounds, three novel 3 substituted-3 （2 chloropyridin-3 yl） 2-（4-（2,6-difluorophenyl）thiazol-2-yl） acrylonitrile compounds were designed and synthesized by using 1 （2,6 difluorophenyl）ethanone and 2-chloronicotinic acid as starting materials, through five steps reaction. Their structures were comfirmed by 1H NMR, IR, MS, and elemental analysis. The preliminary bioassay results indicated that all compounds have some insecticidal and fungicidal activities against aphids, mites and crop pathogens.

关 键 词：3-(2氯吡啶-3-基)-2-[4(2  6-二氟苯基)噻唑2基]-3-羟基丙烯腈 合成 生物活性 

分 类 号：S482[农业科学—农药学]