HPLC法测定咳特灵胶囊中马来酸氯苯那敏的含量  

Determination of Chlorphenamine Maleate in Keteling Capsule by HPLC

作　　者：冯向东[1] 高光伟[2] 黄海欣[1] 

机构地区：[1]河南省南阳市药品检验所,南阳473000 [2]南阳市中心医院,南阳473000

出　　处：《中国药品标准》2009年第1期59-61,共3页Drug Standards of China

摘　　要：目的:建立咳特灵胶囊中马来酸氯苯那敏的含量测定方法。方法:采用HPLC法,使用C18柱,流动相为-0.05mol·L-1KH2PO4溶液-三乙胺-磷酸(10∶90∶0.02∶0.03);流速1.0mL·in-1;柱温35℃;检测波长为219nm。结果:马来酸氯苯那敏进样量在0.035-0.173μg范围内呈良好线性关系,平均回收率(n=9)不低于98%。结论:本法简便,快捷,结果令人满意,可作为咳特灵胶囊的质量控制方法之一。Objective：To establish a method for determining the content of Chlorphenamine Maleate in Keteling Capsule. Methods： The separation was performed in the Cls column at 35℃. The mobile phase consisted of acetonitrile -0. 5 mol · L^-1 potassium phosphate monobasic-triethylamine-phosphoric acid（ 10： 90： 0. 02： 0. 03） with flow rate 1.0 mL · min-1. The detective wavelength was set at 219 nm. Results ：The calibration curves were linear in the ranges of 0.035-0. 173 μg for Chlorphenamine Maleate, the average recoveries were not less than 98%. Conclusion ： The method is simple and rapid with satisfactory results. It is suitable for quality control of Keteling Capsule.

关 键 词：HPLC 咳特灵胶囊 马来酸氯苯那敏 含量 

分 类 号：R927.2[医药卫生—药学] R974.2