用相干光场相位检测法确定生物组织模型的非均匀性  

Location of inhomogeneities within tissue models using coherent optical phase modulation

作　　者：苏畅[1,2,3] 丁海曙[1,2,3] 应金品 王广志[1,2,3] 童剑亮[1,2,3] S.Nioka B.Chance 

机构地区：[1]清华大学电机工程与应用电子技术系 [2]浙江大学物理系 [3]美国宾夕法尼亚大学生物物理和生物化学系

出　　处：《清华大学学报（自然科学版）》1998年第3期72-76,共5页Journal of Tsinghua University(Science and Technology)

基　　金：国家自然科学基金

摘　　要：研究光在混浊介质或生物组织内传播的光场分布的变化，可以间接地获得介质的散射和吸收特性以及介质内部结构变化的有用信息。文章给出了一种描述光在均匀散射介质中传播的光场分布的理论和计算机仿真。在此基础上，通过结合组织近红外光谱学技术（ＮＩＲＳ）与现代激光技术，研究了一种用近红外光学相干相位阵列调制法探测生物组织非均匀性（肿瘤）的新方法。设计了组织光学特性模型，并进行了各种不同条件下实验。探索了生物组织中光场分布与组织特性之间的相互关系。实验表明，给出的检测如大脑和乳腺中存在小吸收体的方法是简单、可行和有效的。The useful information about the properties of scattering and absorption coefficients and the changes of intrinsic structure in turbid medium can be obtained from the study on the optical distribution and interaction between light radiation and medium or biological tissue. This paper gives the theory and computer simulation of optical field distribution in homogeneous scattering medium. By combining the near infrared spectroscopy (NIRS) and modern laser techniques based on above principle, a new method for detection of inhomogeneity (tumor) in tissue is developed by using optical coherent modulated phase array. To investigate the relationship between tissue optical distribution and tissue property, the model phantom of optical property of tissue is designed and the experiments are done in different conditions. The experiment results show that the new noninvasive technique for detecting the small absorber in scattering medium, such as brain and breast is simple, feasible, and valid.

关 键 词：生物组织 相干光场 相位检测 非均匀性 

分 类 号：Q136[生物学—普通生物学] TN215[电子电信—物理电子学]