西佛碱配合物对大肠杆菌代谢抑制的热化学研究  

THERMOCHEMICAL STUDY THE ANTIBACTERIAL ACTIVITY OF SCHIFF BASE COMPLEXES ON THE E. coli

作　　者：黄在银[1] 屈松生[1] 冯英[1] 赵群金 

机构地区：[1]武汉大学化学学院

出　　处：《武汉大学学报（自然科学版）》1998年第2期187-189,共3页Journal of Wuhan University(Natural Science Edition)

基　　金：国家自然科学基金;高等学校博士学科点专项基金

摘　　要：用微量热法研究了水杨醛氨基葡萄糖西佛碱（ＳＧ）配体及其金属配合物和金属离子对大肠杆菌的作用，发现在不同化合物作用下，大肠杆菌的代谢热谱不同，从热谱曲线的差异探讨了ＳＧ系列金属配合物和金属离子对大肠杆菌的抑制情况．Microcalorimtry was used to study antibacterial activities of four kinds of Schiff base and its complexes and two kinds of metal ion compound on E.coli. According to the power time curves, the multiplication rate constant k , the genaration time t g ,antibacterial ratio I and heat q have been calculated from these thermograms. the experimental results show that different kind of compounds has different effect on E.coli, it follows the sequence of Zn SG>SG>Co(Ⅲ) SG>Cu(Ⅱ) SG in 50 mg·L -1 and sequence of Co(Ⅲ) SG～SG>Zn SG>Cu(Ⅱ) SG in 100 mg·L -1 , under the cation of different compounds, their metabolism thermograms are different, the mechanism of their action also different.

关 键 词：西佛碱配合物 大肠杆菌 热化学 药理学 

分 类 号：R969.1[医药卫生—药理学]