高胆血红素血症新生儿换血治疗前后肿瘤坏死因子、可溶性细胞间隙因子的变化  

The discussion on hyperbilirubinemia newborn brings in new blood around thetreatment on the shake-tumor necrosis factor,soluble cell factor changes of space

作　　者：邹建话[1] 祝爱霞[1] 江凡[1] 张修发[1] 麦光兴[1] 卢光进[1] 

机构地区：[1]广东省深圳市宝安区妇幼保健院,518133

出　　处：《中国妇幼保健》2009年第1期53-54,共2页Maternal and Child Health Care of China

基　　金：深圳市科技局自然科学基金资助(项目编号:JH200505310573A)

摘　　要：目的:探讨高胆血红素血症新生儿换血治疗前后血中肿瘤坏死因子、可溶性细胞间隙因子的变化。方法:采用美国RD有限公司提供的双抗体夹心ABC-ELISA法试剂,无菌抽取患儿换血前、中、后静脉血液2.0ml分离血清,试验用。结果:高胆患儿换血前与换血中、换血后比较血中肿瘤坏死因子、可溶性细胞间隙因子差异有统计学意义(均P<0.01)。换血中与换血后比较,血中各种细胞因子差异有统计学意义(均P<0.01)。结论:高胆血红素血症新生儿在换血前、换血中、换血后血中肿瘤坏死因子、可溶性细胞间隙因子均有不同水平的变化,证实了换血疗法是病理性高胆血红素血症新生儿有效的治疗方法。Objective： To investigate the changes of blood tumor necrosis, soluble cell gap factor in hyperbilirubinemia newborn brings during the treatment of neonatal exchange transfusion. Methods： 1.5 ml separate serum of new born was collected before the blood and change blood in, after change blood. The United States RD limited company provide double - antibody contains filling. The expression levels of blood tumor necrosis and soluble cell gap factor were detected by ABC - ELISA Reagent method. Results： The expression levels of tumor necrosis factor and soluble intercellular space factor before the blood with change blood in were different with those after change blood （P 〈 0. 01 ） . The expression levels of other cell factors before the blood with change blood in were different with those after change blood （P 〈 0. 01 ） . Conclusion ： The expression levels of tumor necrosis factor, soluble cell space of neonatal hyperbilirubinemia in the shake - heine hyperlipidemia, shake, shake -blood of are different. The exchange transfusion therapy is a high pathological biliary heine neonatal hyperbilirubinemia.

关 键 词：高胆血红素血症 新生儿 肿瘤坏死因子 可溶性细胞间隙因子 换血治疗 

分 类 号：R715.8[医药卫生—妇产科学]