胎儿生长受限孕妇血清及脐血瘦素水平检测的临床意义  

Clinical significance of measuring serum leptin and cord blood leptin in FGR patient

作　　者：王彦德[1] 刘虹[1] 孙袁[1] 张志萍[1] 吴婉林 

机构地区：[1]贵州省贵阳市妇幼保健院,550003

出　　处：《中国妇幼保健》2009年第2期244-246,共3页Maternal and Child Health Care of China

摘　　要：目的:检测胎儿生长受限(FGR)患者产前及产后和胎儿脐血的瘦素水平,以探讨瘦素与FGR的关系。方法:采用放射免疫分析法(RIA)测定30例FGR患者和40例正常妊娠妇女产前及产后1周血清和胎儿脐血的瘦素水平以及30例健康未孕妇女瘦素水平,并对结果进行相关性分析。结果:①FGR组产前瘦素水平为(23.23±6.75)μg/L,正常妊娠组产前瘦素水平(24.58±5.69)μg/L,两组比较差异无显著性(P>0.05);两组瘦素水平与脐血瘦素水平均无相关性(r=0.237、r=0.199,P均>0.05);两组瘦素水平与新生儿体重均无相关性(r=0.157、r=0.196,P均>0.05)。②FGR组产后瘦素水平为(7.73±2.96)μg/L,与正常妊娠组产后瘦素水平(7.92±2.54)μg/L比较,无显著性差异(P>0.05),两组分别与健康未孕组瘦素水平(7.44±2.48)μg/L比较,也均无显著性差异(P均>0.05)。③FGR组脐血瘦素水平为(5.84±2.68)μg/L,明显低于正常妊娠组脐血瘦素水平(9.37±3.51)μg/L,两组比较有显著性差异(P<0.01);两组脐血瘦素水平与新生儿体重均呈正相关(r=0.412、r=0.392,P均<0.05)。结论:检测母体血清瘦素水平不能作为预测胎儿出生体重的指标,且母体血清瘦素水平与FGR的发生无关;脐血瘦素水平下降可能与FGR的发生有关,且与新生儿出生体重有关。Objective： To measure the leptin of cord blood before and after delivery to study the relationship between fetal growth restriction （FGR） and leptin. Methods： Radioimmunoassay （RIA） was used to measure the leptin level of serum and cord blood of 30 pregnant women with FGR （ FGR group） and 40 normal pregnant women （ normal group） before and 1 week after delivery. The serum leptin were also measured in 30 non - pregnant women. Results： ①The difference of leptin level between the FGR group [ （23.23 ± 6. 75 ）μg/L] and the normal group [ （24. 58 ±5.69） μg/L] before delivery was not significant （P 〉0. 05） . Serum leptin were not correlated with cord blood leptin in two groups （ r = 0. 237, r = 0. 199, P 〉 0. 05 ）. The leptin levels in two group were not correlated with fetus birth weight （r = 0. 157, r=0. 196, P〉0. 05）. ②The difference of leptin level between the FGR group （ （7.73 ±2.96） μg/L] and the normal group [ （7.92±2. 54）μg/L） after delivery was not significant （P 〉0. 05） . There was no significance between two groups and non - pregnant women （7. 44 ±2.48, P 〉 0. 05） . ③Cord blood leptin of FGR group [ （ 5.84 ± 2. 68 ）μg/L 3 were much lower than normal pregnant group （9. 37 ± 3.51 μg/L） （ P 〈 0. 01 ） ; the leptin level of these two groups were positively correlated with fetus birth weight （ r = 0. 412, r = 0. 392, P 〈0.05） . Conclusion： Fetus birth weight can not be predicted by measuring serum leptin of pregnant women; serum leptin of pregnant women is not correlated with FGR; decrease of cord blood leptin may be correlated with FGR and fetus birth weight.

关 键 词：瘦素 胎儿生长受限 脐血 放射免疫分析法 

分 类 号：R714.431[医药卫生—妇产科学]