凝血抗凝异常与反复妊娠丢失的相关性  

Relationship between anticoagulation dysfunction and recurrent pregnancy loss

作　　者：任景芳[1] 郝敏[1] 屈秦红[1] 郭春华[1] 杨林花[1] 侯丽虹[1] 刘秀娥[1] 周玉琦[1] 

机构地区：[1]山西医科大学第二医院,山西太原030001

出　　处：《中国妇幼保健》2009年第5期689-691,共3页Maternal and Child Health Care of China

基　　金：山西省归国留学基金资助项目(项目编号:2005-069)

摘　　要：目的:探讨凝血抗凝异常与不明原因反复妊娠丢失相关性。方法:选择78例(除外口服避孕药)不明原因反复妊娠丢失(RPL)患者及健康妇女60例,分别检测血浆凝血因子FⅡ、FⅤ、FⅧ、FⅨ、D-二聚体(D-D)水平及抗凝血酶(AT)、蛋白C(PC)活性。结果:RPL患者和对照组FⅧ活性水平分别为142.1%±59.8%、103.0%±25.7%,P=0.0001。FⅧ∶C水平大于150%,RPL危险增加4.2倍;FⅧ∶C水平大于130%,RPL危险增加3.3倍。RPL患者和对照组D-D水平分别为(0.38±0.29)mg/L、(0.19±0.12)mg/L,P=0.0001,胎死宫内患者升高尤其显著[(0.40±0.32)mg/L]。RPL患者FⅡ、FⅤ、FⅨ及AT、PC活性与对照组比较无统计学差异。结论:FⅧ活性升高和D-D水平升高是反复妊娠丢失的高危因素,尤其使胎死宫内的危险性显著升高。Objective： The explore the relationship between anticoagulation dysfunction and recurrent pregnancy loss （RPL） . Methods： 78 cases （excluding using oral contraceptives） with the history at least two or more pregnancy loss and 60 healthy women were selected. The levels of FⅡ , FV, FVⅢ, FⅨ, D - Dimer and the activity of protein C and antithrombin （AT） were detected. Results： The levels of FⅧ between RPL group （ 142. 1% ± 59.8% ） and control group （ 103.0% ± 25.7% ） had significant difference （ P = 0. 000 1 ） . When the levels of FⅧ： C were 150% and 130% , the risk rates of RPL were 4. 2 and 3.3, respectively. The levels of D - D were （0. 38 ±0. 29） mg/L in RPL group and （0. 19 ±0. 12） mg/L in control group, the level of D - D was （0. 40 ±0. 32 ） mg/L in women with stillbirth. There was no significant difference in the levels of FⅡ , FV, FIX and AT, PC activities between two groups. Conclusion： High levels of FVⅢ and D- D are associated with an increased relative risk for RPL, especially in stillbirth.

关 键 词：妊娠丢失 凝血 抗凝 

分 类 号：R714.21[医药卫生—妇产科学]