组织工程支架的低温沉积制造工艺参数研究  

Study on low-temperature deposition manufacturing process parameters of tissue engineering scaffold

作　　者：索海瑞[1] 岳秀艳[1,2] 史廷春[1,3] 姜睿智[1] 邱建辉[1] 蔡建辉[1] 王秋君[1] 李艳蕾[1] 

机构地区：[1]杭州电子科技大学生物医学工程与仪器研究所,浙江杭州310018 [2]华北煤炭医学院成教学院,河北唐山063011 [3]河北理工大学机械工程学院,河北唐山063009

出　　处：《机电工程》2009年第3期57-60,共4页Journal of Mechanical & Electrical Engineering

基　　金：浙江省自然科学基金资助项目(Y2080884);浙江省“重中之重”学科建设资助项目(ZX060230);浙江省科技计划资助项目(2008C23077);杭州电子科技大学科研启动基金资助项目(KYS041506008)

摘　　要：低温沉积制造是一种新的快速成形技术。为了将这项技术更好地应用于组织工程支架的制造,根据支架孔隙率的要求,按照一定比例将PLGA和珍珠粉混合,配制成浆料,然后利用低温沉积制造工艺制备了网格型的组织工程支架,并得出了适于加工这种材料的一组工艺参数。主要从软件设定、浆料性质、温控调节和速度匹配4个方面入手,研究了在材料配制、分层和成形机制造等一系列工艺过程中参数对成形结果的影响。实验结果表明,制造出的支架结构规则能满足孔隙率的要求。Low-temperature deposition manufacturing（LDM） is a new rapid prototyping technique. To better applying this technique in the tissue engineering scaffold manufacturing, PLGA and pearl powder were mixed in a certain proportion and diluted into slurry according to the requirement of tissue engineering scaffold porosity. Then the slurry was made into a chessboard-form scaffold. A series of parameters were obtained in compounding of the materials, stratifying and manufacturing by the LDM machine. The impact to the modeling results was mainly studied through four aspects： parameters setting in the software, property of the slurry, regulation of the temperature controlling and match of the velocity. The experiment results indicate that the regularstructure scaffold can meet the porosity requirement.

关 键 词：快速成形 粘度 温度 喷头速度 低温沉积制造 

分 类 号：TH164[机械工程—机械制造及自动化]