化瘀克塞方对急性脑梗死患者神经元特异性烯醇化酶变化的影响  

Effects of "Huayu Kesai Decoction" on Serum Neuron-Specific Enolase in Acute Cerebral Infarction Patients

作　　者：陈家权[1] 李长生[2] 杨晓妮[2] 

机构地区：[1]山东大学医学院,2006级研究生山东济南250012 [2]山东大学附属千佛山医院中医科,山东济南250014

出　　处：《上海中医药杂志》2009年第3期17-19,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：山东省自然科学基金资助项目(Y2005C43)

摘　　要：目的观察化瘀克塞方对急性脑梗死患者神经元特异性烯醇化酶(NSE)变化的影响。方法将70例急性脑梗死症状发生后48h内入院的患者随机分为化瘀克塞方组(37例)和常规治疗组(33例),分别于入院后即时和治疗后的第3、7、14天清晨空腹抽取静脉血测定NSE的浓度,同时进行神经功能缺损评分。结果化瘀克塞方组和常规治疗组患者入院时血清NSE浓度显著高于正常对照组(P<0.05),两组患者之间差异无统计学意义(P>0.05);治疗第3天、第14天两组患者NSE浓度差异无统计学意义(P>0.05),治疗第7天化瘀克塞方组患者血清NSE浓度显著低于常规治疗组(P<0.05)。两组患者在治疗第3天后神经功能缺损评分即较入院时明显改善(P<0.05);治疗第7天、第14天时,组间同期神经功能缺损评分比较,差异有统计学意义(P<0.05)。结论化瘀克塞方能够有效降低急性脑梗死患者血清NSE浓度及神经功能缺损评分,减轻脑损害,对急性脑梗死有神经保护作用。Objective To observe the effects of ＂Huayu Kesai Decoction＂ on serum neuron-specific enolase（NSE） in patients with acute cerebral infarction. Methods Seventy patients with acute cerebral infarction hospitalized within 48 hours after onset were randomized into two groups： treatment group in which 37 cases received ＂Huayu Kesai Decoction＂ treatment and control group in which 33 cases received conventional treatment. Fasting venous blood samples were collected on days 0, 3, 7 and 14 after hospitalization to detect the contents of NSE. Meanwhile, the patients were evaluated using clinical neurological impairment scale. Resuits The serum levels of NSE and neurological impairment scales on admission did not differ between the two groups（ P 〉 0.05 ）, but higher than normal group （ P 〈0.05 ）. The serum level of NSE in treatment group was similar to that in control group on days 3 and 14 （ P 〉0.05 ）, but lower than that in control group on day 7 （P 〈0.05 ）. Compared with neurological impairment scales on admission, both groups showed lowered scales on days 3, 7 and 14 （P 〈0.05 ）, but with striking differences between two groups on days 7 and 14 （ P 〉0.05 ）. Conclusion ＂Huayu Kesai Decoction＂ can effectively reduce the serum level of NSE and neurological impairment scale to relieve brain injury and acute cerebral infarction.

关 键 词：脑梗死 中西医结合疗法 化瘀克塞方 神经元特异性烯醇化酶 神经功能缺损评分 

分 类 号：R277.7[医药卫生—中医学]