海藻低聚糖对放射损伤的防护作用研究  

Radioprotective Effect of the Seaweed Polysaccharides with Low Molecular Weights on the Mice Injured by Irradiaton

作　　者：王海青[1] 李翊[1] 

机构地区：[1]解放军第401医院肿瘤中心,山东青岛266071

出　　处：《中国辐射卫生》2009年第1期33-35,共3页Chinese Journal of Radiological Health

摘　　要：目的探讨海藻低聚糖对受6.0GyX射线照射小鼠的辐射防护作用。方法采用6MVX直线加速器一次全身照射小鼠,3个海藻低聚糖组照射后给药15d。观察小鼠30d存活率、小鼠外周血白细胞总数和红细胞数,脾脏指数,全血谷胱甘肽过氧化物酶(GSH-Px)活力,血清超氧化物歧化酶(SOD)活力。结果海藻低聚糖能加速小鼠外周血白细胞和红细胞数的恢复,明显提高脾脏指数,并且可引起抗氧化物酶GSH-Px和SOD活性显著增高。结论海藻低聚糖对受照射小鼠有明显的辐射防护作用。Objeetive To study the radioprotection effect of the seaweed polysaccharides with low molecular weights on irradiated mice. Methods The seaweed polysaccharides with low molecular weights are applied to mice irradiated with 6.0 Gy rays. 15days after the irradiation, variations in counts of peripheral white blood cell and erythrocytes, spleen index, activities of the GSH - Px and SOD were studied. Results The seaweed polysaccharides with low molecular weights significantly promoted recovery of peripheral white blood cell and erythrocytes, markedly increased spleen index. The seaweed polysaccharide with low molecular weights significantly enhanced activities of the GSH - Px and SOD in blood. Conclusion The seaweed polysaccharides with low moleeular weights have marked radioprotective effect on irradiated mice.

关 键 词：海藻低聚糖 辐射保护 生存率 白细胞总数 抗氧化 

分 类 号：Q691.9[生物学—生物物理学]