基于虚拟仪器技术的血管生物反应器系统的研制  

Development of bioreactor system for the blood vessel based on virtual instrument

作　　者：陈明东[1,2] 张西正[1] 郭新[1] 孙庆兰[1] 

机构地区：[1]军事医学科学院卫生装备研究所,天津300161 [2]南方医科大学生物医学工程学院,广州510515

出　　处：《医用生物力学》2009年第1期34-38,共5页Journal of Medical Biomechanics

基　　金：国家重点基础研究发展计划(973计划)(2005CB623904);天津市自然科学基金重点项目(06YFJZJC02000)

摘　　要：目的生物反应器是组织工程研究的重要载体。本文构造了一种基于虚拟仪器技术的血管生物反应器系统研究平台。方法系统使用曲柄滑块机构压缩和拉伸波纹管,模拟出人体血管内的搏动流。同时利用LabVIEW平台对压力等参数进行测量和控制,系统与PC机连接,可实现远程监控,使整个组织工程生物反应器系统初步实现分步式,自动化。结果实验结果表明,该生物反应器能够对细胞施加合适的生物力学刺激,并准确检测各项参数。结论基于虚拟仪器技术构造的血管生物反应器系统研究平台具有较大的应用推广价值。Objectiva The bioreactor is an important facility for tissue engineering research. A research platform of bioreactor system for blood vessel on the virtual instrument was built. Method Slider-crank mechanism was used in this system to strain the bellows so as to simulate pulse flow of human blood vessels. This system can measure and control such parameters as pressure byusing LabVIEW platform, and byconnected with PC, the remote watch and control could be realized, which primarilyachieved step- control and au- tomatization. Result Experiments show that the bioreactor was able to exert appropriate biomechanical stimulation to cells, and detect various parameters accurately. Conclusions This bioreactor system for bloodvessel on the virtual instrument was valuable in practical application.

关 键 词：生物反应器 虚拟仪器 LABVIEW 组织工程 生物力学 

分 类 号：R318[医药卫生—生物医学工程] Q813.1[医药卫生—基础医学]